Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Das liest die LIBREAS, Nummer #3 (Sommer / Herbst 2018)
Library Ideas, 2018 Redaktion Libreas
doaj +1 more source
Talent management of library and information science professionals: A review of research and future directions. [PDF]
F1000ResRautaray B, Swain DK, Swain C.
europepmc +1 more source
Measuring researchers' potential scholarly impact with structural variations: Four types of researchers in information science (1979-2018). [PDF]
PLoS One, 2020 Hou J, Hou J, Yang X, Chen C.
europepmc +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Princípios científicos que direcionam a ciência e a tecnologia da informação digital
TransinformaçãoNo quadro de um projeto epistemológico, apresenta-se um breve estudo crítico de cinco princípios científicos que direcionam e caracterizam, atualmente, os novos paradigmas informacionais presentes na Ciência e na Tecnologia da Informação Digital.
Yves-François Le Coadic
doaj
Competencies required to make use of Information Science and Technology among Japanese medical students: a cross-sectional study. [PDF]
BMC Med EducOta Y, Asada Y, Mieno M, Matsuyama Y.
europepmc +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Enhancing the quality and efficiency of regulatory science literature reviews through innovation and collaboration with library and information science experts. [PDF]
Front Med (Lausanne)Stevens ER, Laynor G.
europepmc +1 more source