Results 101 to 110 of about 15,399,652 (281)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Technical approbation of the method for testing on vibration effects of on-board radio-electronic equipment of spacecrafts [PDF]

open access: yesКосмические аппараты и технологии
The article provides a description of the developed method, which ensures the correct realization of mechanical tests of on-board radio-electronic equipment of spacecrafts for vibration effects in the process of ground experimental testing.
A. А. Khvalko   +4 more
doaj  

Geoid Undulation Model as Vertical Reference in Indonesia

open access: yesScientific Data
Indonesia released a new regional geoid model in 2020—the Indonesian Geoid 2020 (INAGEOID2020). It covers the Indonesian region with a spatial resolution of 0.01 × 0.01 degree with the unit in meters.
Arisauna Pahlevi   +19 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

System combination with extra alignment information [PDF]

open access: yes, 2012
This paper provides the system description of the IHMM team of Dublin City University for our participation in the system combination task in the Second Workshop on Applying Machine Learning Techniques to Optimise the Division of Labour in Hybrid MT ...
Liu, Qun   +3 more
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Information System Design for Micro Credit Banks [PDF]

open access: yes, 2003
Developments in the banking system under its wings for small entrepreneurs (market traders)who very much and is the economic backbone of the people in Indonesia. To assist the smallentrepreneurs who are usually very shy in touch with the bank. This micro-
Widianti, L. W. (Linda)
core  

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