Results 91 to 100 of about 4,686,984 (308)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The JINR Tier1 Site Simulation for Research and Development Purposes

EPJ Web of Conferences, 2016
Distributed complex computing systems for data storage and processing are in common use in the majority of modern scientific centers. The design of such systems is usually based on recommendations obtained via a preliminary simulated model used and ...
Korenkov V., Nechaevskiy A., Ososkov G., Pryahina D., Trofimov V., Uzhinskiy A., Voytishin N.   +6 more
doaj   +1 more source

Fractal representations in image processing of remote sensing of the earth [PDF]

E3S Web of Conferences
This article explores the application of fractal representations in the image processing of remote sensing data for Earth observation. Fractals, with their self-similar properties and complex patterns, offer a powerful mathematical framework for ...
Khudaiberdiev Mizaakbar, Khan Igor, Tojiboyev Bobomurod, Achilov Bahodir   +3 more
doaj   +1 more source

Information Technologies, Economic Growth and Productivity Shocks [PDF]

This paper develops a multi-sectoral endogenous growth model in order to reproduce some of the essential characteristics of the so-called ÒICT RevolutionÓ.
Claudio MATTALIA
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Editorial: Applications of geospatial information technologies and spatial statistics in health services research. [PDF]

Front Public Health, 2023
Song C, Wang X, Ge E, Shi X, Pan J.
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Barriers and facilitators of using health information technologies by women: a scoping review. [PDF]

BMC Med Inform Decis Mak, 2023
Moulaei K, Moulaei R, Bahaadinbeigy K.
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Information and communication technologies for the poor: [PDF]

This brief is based on Information and Communication Technologies for Development and Poverty Reduction: The Potential of Telecommunications, ed. Maximo Torero and Joachim von Braun (Johns Hopkins University Press and IFPRI, 2006) "The variety of views ...
Torero, Maximo, von Braun, Joachim
core