Results 101 to 110 of about 4,686,984 (308)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Photonic quantum technologies

open access: yes, 2009
The first quantum technology, which harnesses uniquely quantum mechanical effects for its core operation, has arrived in the form of commercially available quantum key distribution systems that achieve enhanced security by encoding information in photons
A Aspect   +120 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Information & communication technologies - panacea for traffic congestion? [PDF]

open access: yes
As road pricing, telematics and logistics evolve, information and communication technologies (ICT) aim directly at making traffic flow more efficiently in a given infrastructure.
Stefan Heng
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Preface

open access: yesInformation Processing in Agriculture, 2014
Daoliang Li, Prof. Director of China-EU Center for Information & Communication Technologies in Agriculture (CICTA), China Agricultural University and Chair of WG5.14, IFIP TC5
doaj   +1 more source

Building an IT Taxonomy with Co-occurrence Analysis, Hierarchical Clustering, and Multidimensional Scaling [PDF]

open access: yes, 2010
Different information technologies (ITs) are related in complex ways. How can the relationships among a large number of ITs be described and analyzed in a representative, dynamic, and scalable way?
Fleischmann, Kenneth R.   +4 more
core  

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