Results 81 to 90 of about 1,316,855 (265)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
The JINR Tier1 Site Simulation for Research and Development Purposes
EPJ Web of Conferences, 2016 Distributed complex computing systems for data storage and processing are in common use in the majority of modern scientific centers. The design of such systems is usually based on recommendations obtained via a preliminary simulated model used and ...
Korenkov V. +6 more
doaj +1 more source
International Journal of Serious Games, 2019 This study evaluates user acceptance of a gamification-enabled collaboration and knowledge sharing platform that has been developed for use by personnel in industrial work environments, aiming at increasing motivation for knowledge exchange. The platform
Stylianos Zikos +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Editorial: Applications of geospatial information technologies and spatial statistics in health services research. [PDF]
Front Public Health, 2023 Song C, Wang X, Ge E, Shi X, Pan J.
europepmc +1 more source
Ethics and Information Technology
Australasian Journal of Information Systems, 1997 The versatility and adaptability of information technology (IT) offer many potential benefits to society, its organisations and its citizens, but there are also associated risks. The social and ethical implications of this technology warrant special attention and have resulted in the creation of information ethics as a discrete area of study.
openaire +3 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Barriers and facilitators of using health information technologies by women: a scoping review. [PDF]
BMC Med Inform Decis Mak, 2023 Moulaei K, Moulaei R, Bahaadinbeigy K.
europepmc +1 more source