Results 61 to 70 of about 21,736,361 (314)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Minutes: Senate Committee on Information Technologies: March 2, 2010

, 2010
Information Technology six year plan presentation; advancing excellence in Information TechnologyUniversity of Minnesota: Senate Committee on Information Technologies. (2010).
University of Minnesota: Senate Committee on Information Technologies
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CONCEPT OF AUTOMATED RESPONSE TO THREATS IN CORPORATE DATABASES IN REAL-TIME MODE

Кібербезпека: освіта, наука, техніка
The article presents a concept of automated real-time threat response in corporate databases, developed with consideration of current trends in cyber threat evolution and the limitations of existing protection mechanisms. The relevance of the research is
Світлана Легомінова, Тетяна Капелюшна, Юрій Щавінський, Михайло Запорожченко, Олександр Будзинський   +4 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Minutes: Senate Committee on Information Technologies (SCIT): October 10, 2022

, 2022
In these minutes: NXT GEN PlatformsUniversity of Minnesota: Senate Committee on Information Technologies. (2022). Minutes: Senate Committee on Information Technologies (SCIT): October 10, 2022.
University of Minnesota: Senate Committee on Information Technologies
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Quality - Information Technologies - Consumer

Amfiteatru Economic, 2011
Companies and consumers live in a world where the Internet is one of its defining elements, information technologies increasingly marking all the activities undertaken by them. With increased access to information, with a strong desire for knowledge, and
Vasile Dinu
doaj  

Method for assessing the risk of user compromise based on individual security profile

Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska
This article presents a method for assessing the risk of user compromise in corporate information systems caused by social engineering cyberattacks.
Svitlana Lehominova, Mykhailo Zaporozhchenko, Tetiana Kapeliushna, Yuriy Shchavinsky, Tetiana Muzhanova   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Minutes: Senate Committee on Information Technologies: November 1, 2011

, 2011
University of Minnesota: Senate Committee on Information Technologies. (2011). Minutes: Senate Committee on Information Technologies: November 1, 2011.
University of Minnesota: Senate Committee on Information Technologies
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