Results 61 to 70 of about 1,316,855 (265)

Exploring the prosociality domains of trust and cooperation, through single and cooperative digital gameplay in Path of Trust.

International Journal of Serious Games, 2016
Amidst an ongoing debate surrounding the traditional dichotomy of whether video games are good or bad for children, in this paper we present Path of Trust, a novel, prosocial game that aims at helping children understand the importance of teamwork and ...
Konstantinos Cornelis Apostolakis, Athanasios Psaltis, Kiriakos Stefanidis, Kyriaki Kaza, Spyridon Thermos, Kosmas Dimitropoulos, Evangelia Dimaraki, Petros Daras   +7 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

CONCEPT OF AUTOMATED RESPONSE TO THREATS IN CORPORATE DATABASES IN REAL-TIME MODE

Кібербезпека: освіта, наука, техніка
The article presents a concept of automated real-time threat response in corporate databases, developed with consideration of current trends in cyber threat evolution and the limitations of existing protection mechanisms. The relevance of the research is
Світлана Легомінова, Тетяна Капелюшна, Юрій Щавінський, Михайло Запорожченко, Олександр Будзинський   +4 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Quality - Information Technologies - Consumer

Amfiteatru Economic, 2011
Companies and consumers live in a world where the Internet is one of its defining elements, information technologies increasingly marking all the activities undertaken by them. With increased access to information, with a strong desire for knowledge, and
Vasile Dinu
doaj  

Method for assessing the risk of user compromise based on individual security profile

Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska
This article presents a method for assessing the risk of user compromise in corporate information systems caused by social engineering cyberattacks.
Svitlana Lehominova, Mykhailo Zaporozhchenko, Tetiana Kapeliushna, Yuriy Shchavinsky, Tetiana Muzhanova   +4 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source