Results 71 to 80 of about 1,320,225 (265)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
The JINR Tier1 Site Simulation for Research and Development Purposes
EPJ Web of Conferences, 2016 Distributed complex computing systems for data storage and processing are in common use in the majority of modern scientific centers. The design of such systems is usually based on recommendations obtained via a preliminary simulated model used and ...
Korenkov V. +6 more
doaj +1 more source
International Journal of Serious Games, 2019 This study evaluates user acceptance of a gamification-enabled collaboration and knowledge sharing platform that has been developed for use by personnel in industrial work environments, aiming at increasing motivation for knowledge exchange. The platform
Stylianos Zikos +5 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Editorial: Applications of geospatial information technologies and spatial statistics in health services research. [PDF]
Front Public Health, 2023 Song C, Wang X, Ge E, Shi X, Pan J.
europepmc +1 more source
Ethics and Information Technology
Australasian Journal of Information Systems, 1997 The versatility and adaptability of information technology (IT) offer many potential benefits to society, its organisations and its citizens, but there are also associated risks. The social and ethical implications of this technology warrant special attention and have resulted in the creation of information ethics as a discrete area of study.
openaire +3 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Barriers and facilitators of using health information technologies by women: a scoping review. [PDF]
BMC Med Inform Decis Mak, 2023 Moulaei K, Moulaei R, Bahaadinbeigy K.
europepmc +1 more source