Results 51 to 60 of about 4,612,999 (280)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Exploring the prosociality domains of trust and cooperation, through single and cooperative digital gameplay in Path of Trust.

International Journal of Serious Games, 2016
Amidst an ongoing debate surrounding the traditional dichotomy of whether video games are good or bad for children, in this paper we present Path of Trust, a novel, prosocial game that aims at helping children understand the importance of teamwork and ...
Konstantinos Cornelis Apostolakis, Athanasios Psaltis, Kiriakos Stefanidis, Kyriaki Kaza, Spyridon Thermos, Kosmas Dimitropoulos, Evangelia Dimaraki, Petros Daras   +7 more
doaj   +1 more source

Evaluating the integration of supply chain information systems: A case study [PDF]

, 2004
Supply chain management (SCM) is the integrated management of business links, information flows and people. It is with this frame of reference that information systems integration from both intra- and inter-organisational levels becomes significant ...
Bartezzaghi, Brown, Christopher, D'Amours, Denzin, Duke, Gattorna, Gjerdrum, Gunnarsson, Helm, Janesick, Kalakota, Kalakota, Lambert, Linthicum, Linthicum, Linthicum, Loinsky, Marinos Themistocleous, Miles, Peter E.D Love, Ring, Sharma, Spekman, Stefansson, Themistocleous, Themistocleous, Themistocleous, Themistocleous, Thonemann, Zahir Irani   +30 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Information Technology & psychiatry

Archives of Mental Health, 2010
The advances in the area of Information Technology has a pervasive influence on the society. There is no field where IT cannot help in improving its quality. IT has improved the processing speed of information, ease with which information can be transferred and shared.
openaire   +2 more sources

Recommendations for Using Online Social Networking Technologies to Reduce Inaccurate Online Health Information [PDF]

, 2011
This short report highlights patients' increasing use of the Internet and online social networking technologies to seek health information, and the consequences of gaining information from sites with biased or inaccurate health information. Reflecting on
Young, SD
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Analytical Processing of Applied Tasks Conceptual Models at Design of Information-Active Systems [PDF]

EPJ Web of Conferences, 2019
The article describes the concept of the methodology of intellectual labor automation, a formal description of the conceptual model (CM) at the object level, and also a description of the analytical processing of CM. The conceptual model is the basis for
Novoselova Olga, Ruzheynikov Anton, Gavrilov Andrey   +2 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source