Results 51 to 60 of about 4,635,546 (299)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Stabilization of parameters of optoelectronic devices on semiconductor emitters [PDF]

E3S Web of Conferences
The current state of using LEDs for gas analysis, environmental monitoring, hygrometry, medical diagnostics, and communication systems is analyzed. Existing methods for ensuring the stability of LED parameters, their significance, and application in ...
Kuldashov Obbosjon, Rayimdjanova Odinakhon, Djalilov Bahrom, Ergashev Shohbozjon, Toxirova Sarbinoz, Muhammadjonov Azamatjon   +5 more
doaj   +1 more source

Information technologies that facilitate care coordination: provider and patient perspectives [PDF]

, 2018
Health information technology is a core infrastructure for the chronic care model, integrated care, and other organized care delivery models. From the provider perspective, health information exchange (HIE) helps aggregate and share information about a ...
Dixon, Brian E., Embi, Peter J., Haggstrom, David A.   +2 more
core   +1 more source

Information Technology & psychiatry

Archives of Mental Health, 2010
The advances in the area of Information Technology has a pervasive influence on the society. There is no field where IT cannot help in improving its quality. IT has improved the processing speed of information, ease with which information can be transferred and shared.
openaire   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Evaluating the integration of supply chain information systems: A case study [PDF]

, 2004
Supply chain management (SCM) is the integrated management of business links, information flows and people. It is with this frame of reference that information systems integration from both intra- and inter-organisational levels becomes significant ...
Bartezzaghi, Brown, Christopher, D'Amours, Denzin, Duke, Gattorna, Gjerdrum, Gunnarsson, Helm, Janesick, Kalakota, Kalakota, Lambert, Linthicum, Linthicum, Linthicum, Loinsky, Marinos Themistocleous, Miles, Peter E.D Love, Ring, Sharma, Spekman, Stefansson, Themistocleous, Themistocleous, Themistocleous, Themistocleous, Thonemann, Zahir Irani   +30 more
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Exploring the prosociality domains of trust and cooperation, through single and cooperative digital gameplay in Path of Trust.

International Journal of Serious Games, 2016
Amidst an ongoing debate surrounding the traditional dichotomy of whether video games are good or bad for children, in this paper we present Path of Trust, a novel, prosocial game that aims at helping children understand the importance of teamwork and ...
Konstantinos Cornelis Apostolakis, Athanasios Psaltis, Kiriakos Stefanidis, Kyriaki Kaza, Spyridon Thermos, Kosmas Dimitropoulos, Evangelia Dimaraki, Petros Daras   +7 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source