Results 61 to 70 of about 4,612,999 (280)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Prediction of quality software quality indicators with applied modifications of integrated gradiates methods

open access: yesInformatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska
The article is devoted to modern software systems (SS) and improving their quality using machine learning methods, including the Integrated Gradients (IG) method.
Anton Shantyr   +4 more
doaj   +1 more source

First results in the development of a mobile robot with trajectory planning and object recognition capabilities

open access: yesOpen Engineering, 2016
The use of mobile robots is becoming popular in many areas of service because they ensure safety and good performance while working in dangerous or unreachable locations. Areas of application of mobile robots differ from educational research to detection
Islamgozhayev Talgat   +4 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

STATISTICAL PROPERTIES OF THE PSEUDORANDOM SEQUENCE GENERATION ALGORITHM

open access: yesScientific Journal of Astana IT University
One of the most important issues in the design of cryptographic algorithms is studying their cryptographic strength. Among the factors determining the reliability of cryptographic algorithms, a good pseudorandom sequence generator, which is used for key ...
Ardabek Khompysh   +4 more
doaj   +1 more source

Information technologies, embodiment and growth [PDF]

open access: yes
This paper studies the conditions under which an IT revolution may endogenously occur. To this end, we construct an endogenous growth multisectoral model with a preeminent IT sector.
Boucekkine, Raouf, de la Croix, David
core  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Quality - Information Technologies - Consumer

open access: yesAmfiteatru Economic, 2011
Companies and consumers live in a world where the Internet is one of its defining elements, information technologies increasingly marking all the activities undertaken by them. With increased access to information, with a strong desire for knowledge, and
Vasile Dinu
doaj  

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