Results 121 to 130 of about 8,942,452 (348)

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Consumer Attitudes Regarding Information Technology Usage [PDF]

This paper intends to formulate the hypotheses for the factors that influence individuals to adopt Information Technology as a mean to conduct the traditional services.
Durmus YORUK, Khalil MD NOR, Liliana Mihaela MOGA   +2 more
core  

Usefulness of Information Retrieval Technology

, 1969
Shosuke Watanabe
openalex   +2 more sources

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

The global information technology report 2014 [PDF]

Executive summary When The Global Information Technology Report (GITR) and the Networked Readiness Index (NRI) were created more than 13 years ago, the attention of decision makers was focused on how to develop strategies that would allow them to ...
Benat Bilbao-Osorio, Bruno Lanvin, Soumitra Dutta   +2 more
core  

THE PLACE AND THE ROLE OF THE INFORMATION AND COMMUNICATION TECHNOLOGIES IN THE SYSTEM OF EDUCATION IN EUROPEAN UNION COUNTRIES

, 1970
Oksana V. Ovcharuk
openalex   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

MODELS OF THE EFFECTIVE USE OF INFORMATION AND COMMUNICATION AND DISTANCE TECHNOLOGIES IN HIGHER SCHOOL

, 1970
Наталія Морзе, Olena Hlazunova   +1 more
openalex   +2 more sources

Information Technology and Corporate Strategy: A Research Perspective [PDF]

, 1986
J. Yannis Bakos, Michael E. Treacy
openalex   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source