Results 91 to 100 of about 1,024,528 (268)

Mimicking classical noise in ion channels by quantum decoherence

Scientific Reports
The mechanism of selectivity in ion channels is still an open question in biology. Recent studies suggest that the selectivity filter may exhibit quantum coherence, which could help explain how ions are selected and conducted.
Mina Seifi, Ali Soltanmanesh, Afshin Shafiee   +2 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Quantifying coupling and causality in dynamic bivariate systems: a unified framework for time-domain, spectral, and information-theoretic analysis

Frontiers in Network Physiology
Understanding the underlying dynamics of complex real-world systems, such as neurophysiological and climate systems, requires quantifying the functional interactions between the system units under different scenarios.
Laura Sparacino, Helder Pinto, Chiara Barà, Yuri Antonacci, Riccardo Pernice, Ana Paula Rocha, Luca Faes, Luca Faes   +7 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Smart Summary: A Distributed Medical Recommender System for Patients in the ICU Using Neural Networks

IEEE Access
In the medical domain, particularly in intensive care units (ICUs), the immense volume of patient data presents a significant challenge for clinicians, often resulting in the oversight of critical information or excessive time consumption in accessing it.
Ahmad Ayad, Yu-Hsuan Tai, Guido Dartmann, Anke Schmeink   +3 more
doaj   +1 more source

Measurement, theory, and information

Information and Control, 1979
ReferencesA general scheme is presented for explaining the inter-relation of measurement, theory, and information. Ordinary measurement theory is enriched with ideas from quantum physics and coupled to the concept of informations on lattices. Algebraic properties of the class of informations are studied, and it is shown that probability theories are ...
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Early thrombus detection in ECMO with optimized impedance measurements: A simulative study

Journal of Electrical Bioimpedance
Extracorporeal oxygenation supports patients with severe cardiac or respiratory failure, with the oxygenator providing critical gas exchange. Thrombus formation in the oxygenator can impair efficiency and increase risks such as hemolysis and embolism ...
Slapal Filip, Silva Diogo F., Leonhardt Steffen, Walter Marian   +3 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source