Results 71 to 80 of about 14,095,467 (307)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Dynamic Spectral Modulation on Meta‐Waveguides Utilizing Liquid Crystal

Advanced Science, 2023
The integration of metasurfaces and optical waveguides is gradually attracting the attention of researchers because it allows for more efficient manipulation and guidance of light.
Chengkun Dong, Ziwei Zhou, Xiaowen Gu, Yichen Zhang, Guodong Tong, Zhihai Wu, Hao Zhang, Wenqi Wang, Jun Xia, Jun Wu, Tangsheng Chen, Jinping Guo, Fan Wang, Fengfan Tang   +13 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Simultaneous Generation of Multiple Three-Dimensional Tractor Curve Beams

Nanoscale Research Letters, 2019
A tractor beam, which has the ability to attract objects, is a class of special optical beams. Currently, people are using the holographic technology to shape complex optical tractor beams for both fundamental research and practical applications. However,
Jun Wu, Xinquan Tang, Jun Xia
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Characterization and Optimization of Field of View in a Holographic Waveguide Display

IEEE Photonics Journal, 2017
The paper presents the characterization of the field of view (FOV) in a holographic waveguide display (HWD) with a broadband spectrum image source. The influences of parameters such as grating slanted angle of volume holographic grating (VHG), grating ...
Zhongwen Shen, Yuning Zhang, Yishi Weng, Xiaohua Li   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Real-Time Electro-Optical Tunable Hyperlens Under Subwavelength Scale

IEEE Photonics Journal, 2018
Hyperlens consisted by period plasmonic metamaterials is an interesting technology for the optical imaging of arbitrary objects beyond the diffraction limit in the far field, which has great potential applications in nanophotonics.
Dan Su, Xiao-Yang Zhang, Yuan-Liang Ma, Feng Shan, Jing-Yuan Wu, Xing-Chang Fu, Li-Jiang Zhang, Ke-Qiang Yuan, Tong Zhang   +8 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source