Results 31 to 40 of about 366 (127)

The Potential Role of Synovial T Cell Infiltration Following Knee Joint Injury in Symptoms and Progression to Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective Identification of osteoarthritis (OA)–specific synovial inflammatory pathways and their temporal relevance is critical for therapeutic targeting. We compared mononuclear inflammatory/immune cell responses following joint injury that does or does not lead to OA to define bona fide OA‐associated cellular events.
Babak Moradi, Miriam T. Jackson, Cindy C. Shu, Susan M. Smith, Margaret M. Smith, Sanaa Zaki, Hadrian Platzer, Nils Rosshirt, David Giangreco, Carla R. Scanzello, Christopher B. Little   +10 more
wiley   +1 more source

Triple Technique for Neglected Locked Patellar Dislocation With Lateral Release, Synthetic Medial Patellofemoral Ligament, and Peroneus Longus Autograft Medial Quadriceps Tendon‐Femoral Ligament Reconstruction

Arthroscopy Techniques, EarlyView.
Abstract Patellar dislocation is a frequent emergency presentation. First‐time dislocations are associated with medial patellofemoral ligament injury in up to 94.7% of cases. Although many reduce spontaneously, reduction under anesthesia may be required.
Hesham Ahmed Abdul Galil, Moustafa Kamal El Gafary, Amr Samy M. El Hady, Ahmad Hany Khater   +3 more
wiley   +1 more source

CD8+ T‐cells, CD86+ macrophages and TNF‐α signalling pathways are correlated with fetlock osteoarthritis in racehorses

Equine Veterinary Journal, EarlyView.
Abstract Background There is emerging evidence for the role of the immune system in osteoarthritis (OA) pathophysiology; however, little is known about how immune cells and the synovial transcriptome are altered in naturally occurring equine OA. Objectives To evaluate synovial fluid (SF) and synovial membrane (SM) immune cell populations and the SM ...
E. J. Secor, E. N. Chow, M. Thomas, L. Johnson, A. Siefert, B. Wagner, J. B. Engiles, H. L. Reesink   +7 more
wiley   +1 more source

Mapping Fatty Acid Composition in the Human Knee: Short‐Term Repeatability at 3T

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Alterations in periarticular lipid composition are implicated in musculoskeletal diseases, yet short‐term reliability of MRI‐based triglyceride composition mapping in the knee is not fully established. Purpose To evaluate 1‐week repeatability of proton‐density fat fraction (PDFF) and triglyceride fatty‐acid composition—saturated ...
Dimitri Martel, Anne Adlung, Baptiste Busi, Rollanda Bernadin, Yagni Shah, Thorsten Kirsch, Richard Kijowski, Guillaume Madelin, Amparo Ruiz   +8 more
wiley   +1 more source

Osteoarthritis: An Immuno‐Inflammatory Disease‐Mechanisms of Immune Cell Dysregulation and Potential Therapeutic Strategies

Med Research, EarlyView.
This review summarizes the immuno‐inflammatory mechanisms driving the pathogenesis of osteoarthritis (OA), extending beyond the traditional view of OA as a purely degenerative disease to incorporate immune cell infiltration, inflammatory factor release, and the formation of a chronic low‐grade inflammatory microenvironment.
Qingqiang Lei, Xiaoxian Lou, Xu Su, Shubao Liu, Yanli Tong, Jie Chen, Xuerui Chen, Wenjun Mao, Hui Yu, Liangbin Lin   +9 more
wiley   +1 more source

Phenotypic and functional properties of dedifferentiated fat cells derived from infrapatellar fat pad

Regenerative Therapy, 2022
Introduction: Mature adipocyte-derived dedifferentiated fat cells (DFATs) are mesenchymal stem cell (MSC)-like cells with high proliferative ability and multilineage differentiation potential.
Koji Tanimoto, Taro Matsumoto, Yuki Nagaoka, Tomohiko Kazama, Chii Yamamoto, Koichiro Kano, Masahiro Nagaoka, Shu Saito, Yasuaki Tokuhashi, Kazuyoshi Nakanishi   +9 more
doaj   +1 more source

Newly identified intervertebral fat pad degenerates after intervertebral disc injury in a rat model of degeneration

Journal of Anatomy, Volume 249, Issue 2, Page 435-444, August 2026.
This study characterizes a newly‐described intervertebral fat pad (IVFP) anterior to rat IVDs, with evidence for its existence in mice and human IVDs as well. In rats, the IVFP gradually degenerated following IVD injury with changes in adipocyte size and fibrous tissue infiltration, suggesting it could play a functional role in IVD health and ...
Niklas H. Koehne, Irina Heggli, Agnieszka A. Karol, Alon Lai, Svenja Illien‐Jünger, Andrew C. Hecht, Nilsson Holguin, James C. Iatridis   +7 more
wiley   +1 more source

Exploratory pilot study of infrapatellar fat pad inflammation and treatment response in anterior knee pain: a single-center, ultrasound-guided injection trial in osteoarthritis and non-OA cohorts

Egyptian Rheumatology and Rehabilitation
Background Osteoarthritis (OA) is a leading cause of knee pain, and the infrapatellar fat pad (IPFP) may play a role via local inflammation. Objective This exploratory pilot study assessed infrapatellar fat pad (IPFP) inflammation using Doppler ...
Amira Abd Allah, Nadia Salah, Mohammed Ali, Soha Eldessouki   +3 more
doaj   +1 more source

Genetic mapping of distal femoral, stifle, and tibial radiographic morphology in dogs with cranial cruciate ligament disease.

PLoS ONE, 2019
Cranial cruciate ligament disease (CCLD) is a complex trait. Ten measurements were made on orthogonal distal pelvic limb radiographs of 161 pure and mixed breed dogs with, and 55 without, cranial cruciate partial or complete ligament rupture.
Eleni Healey, Rachel J Murphy, Jessica J Hayward, Marta Castelhano, Adam R Boyko, Kei Hayashi, Ursula Krotscheck, Rory J Todhunter   +7 more
doaj   +1 more source

Infrapatellar fat pad area on knee MRI: does it correlate with the extent of knee osteoarthritis?

The Egyptian Journal of Radiology and Nuclear Medicine, 2021
Background Osteoarthritis (OA) of the knee joint is a common cause of chronic disability in older adults. During the past 10 years, the infrapatellar fat pad (IPFP) has emerged as a new player in the pathogenesis of knee OA.
Eman Ragab, Dena Serag
doaj   +1 more source