Results 51 to 60 of about 6,036 (219)

Engineering zonal cartilaginous tissue by modulating oxygen levels and mechanical cues through the depth of infrapatellar fat pad stem cell laden hydrogels. [PDF]

, 2016
Engineering tissues with a structure and spatial composition mimicking those of native articular cartilage (AC) remains a challenge. This study examined if infrapatellar fat pad-derived stem cells (FPSCs) can be used to engineer cartilage grafts with a ...
Albro, Albro, Angele, Bian, Buckley, Buckley, Buckley, Buckley, Buckley, Carroll, Chen, Cicione, De Bari, English, Gannon, Gannon, Gannon, Grad, Grimshaw, Haugh, Holmes, Huang, Ignat'eva, Kafienah, Kanichai, Khan, Khoshgoftar, Kim, Kim, Kisiday, Klein, Klein, Klein, Klein, Krinner, Lee, Li, Luo, Mansour, Maroudas, Mesallati, Meyer, Mow, Mow, Mow, Muir, Nagel, Nagel, Narmoneva, Ng, Ng, Ng, Nguyen, Nguyen, Nugent-Derfus, Otte, Roth, Schinagl, Sengers, Sharma, Silver, Thorpe, Thorpe, Vinardell, Vinardell, Wang, Williamson, Wilson, Zhou   +68 more
core   +1 more source

Chemical composition of the infrapatellar fat pad of swine [PDF]

Journal of Anatomy, 2004
AbstractThe porcine infrapatellar fat pad is a structure composed of adipocytes and adipose connective tissues. Limited information is available concerning its chemical composition. Samples of the fat pad collected from young hogs were dissected into two portions: a relatively hard core of the pad with cushioning properties (inner tissue), and a soft ...
Nakano, Takuo, Wang, Yan Wen, Ozimek, Lech, Sim, Jeong S.   +3 more
openaire   +3 more sources

The Potential Role of Synovial T Cell Infiltration Following Knee Joint Injury in Symptoms and Progression to Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective Identification of osteoarthritis (OA)–specific synovial inflammatory pathways and their temporal relevance is critical for therapeutic targeting. We compared mononuclear inflammatory/immune cell responses following joint injury that does or does not lead to OA to define bona fide OA‐associated cellular events.
Babak Moradi, Miriam T. Jackson, Cindy C. Shu, Susan M. Smith, Margaret M. Smith, Sanaa Zaki, Hadrian Platzer, Nils Rosshirt, David Giangreco, Carla R. Scanzello, Christopher B. Little   +10 more
wiley   +1 more source

CD8+ T‐cells, CD86+ macrophages and TNF‐α signalling pathways are correlated with fetlock osteoarthritis in racehorses

Equine Veterinary Journal, EarlyView.
Abstract Background There is emerging evidence for the role of the immune system in osteoarthritis (OA) pathophysiology; however, little is known about how immune cells and the synovial transcriptome are altered in naturally occurring equine OA. Objectives To evaluate synovial fluid (SF) and synovial membrane (SM) immune cell populations and the SM ...
E. J. Secor, E. N. Chow, M. Thomas, L. Johnson, A. Siefert, B. Wagner, J. B. Engiles, H. L. Reesink   +7 more
wiley   +1 more source

Newly identified intervertebral fat pad degenerates after intervertebral disc injury in a rat model of degeneration

Journal of Anatomy, EarlyView.
This study characterizes a newly‐described intervertebral fat pad (IVFP) anterior to rat IVDs, with evidence for its existence in mice and human IVDs as well. In rats, the IVFP gradually degenerated following IVD injury with changes in adipocyte size and fibrous tissue infiltration, suggesting it could play a functional role in IVD health and ...
Niklas H. Koehne, Irina Heggli, Agnieszka A. Karol, Alon Lai, Svenja Illien‐Jünger, Andrew C. Hecht, Nilsson Holguin, James C. Iatridis   +7 more
wiley   +1 more source

Phenotypic and functional properties of dedifferentiated fat cells derived from infrapatellar fat pad

Regenerative Therapy, 2022
Introduction: Mature adipocyte-derived dedifferentiated fat cells (DFATs) are mesenchymal stem cell (MSC)-like cells with high proliferative ability and multilineage differentiation potential.
Koji Tanimoto, Taro Matsumoto, Yuki Nagaoka, Tomohiko Kazama, Chii Yamamoto, Koichiro Kano, Masahiro Nagaoka, Shu Saito, Yasuaki Tokuhashi, Kazuyoshi Nakanishi   +9 more
doaj   +1 more source

Extracellular Vesicles in Osteoarthritis: From Pathogenic Mediators to Engineered Therapeutics in a Precision Medicine Roadmap

Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.
ABSTRACT Osteoarthritis (OA) remains without disease‐modifying sssstherapies, in part due to biological heterogeneity and a hostile joint microenvironment that undermines one‐size‐fits‐all interventions. Extracellular vesicles (EVs) play a dual role in OA pathophysiology: endogenous EVs disseminate pro‐inflammatory and catabolic signals that propagate ...
Duc‐Hiep Bach, Van Giang Bui, Thanh Liem Nguyen   +2 more
wiley   +1 more source

Genetic mapping of distal femoral, stifle, and tibial radiographic morphology in dogs with cranial cruciate ligament disease.

PLoS ONE, 2019
Cranial cruciate ligament disease (CCLD) is a complex trait. Ten measurements were made on orthogonal distal pelvic limb radiographs of 161 pure and mixed breed dogs with, and 55 without, cranial cruciate partial or complete ligament rupture.
Eleni Healey, Rachel J Murphy, Jessica J Hayward, Marta Castelhano, Adam R Boyko, Kei Hayashi, Ursula Krotscheck, Rory J Todhunter   +7 more
doaj   +1 more source

Infrapatellar fat pad area on knee MRI: does it correlate with the extent of knee osteoarthritis?

The Egyptian Journal of Radiology and Nuclear Medicine, 2021
Background Osteoarthritis (OA) of the knee joint is a common cause of chronic disability in older adults. During the past 10 years, the infrapatellar fat pad (IPFP) has emerged as a new player in the pathogenesis of knee OA.
Eman Ragab, Dena Serag
doaj   +1 more source

Three dimensional anatomy of the anterior cruciate ligament: a new approach in anatomical orthopedic studies and a literature review [PDF]

, 2012
Background: The anterior cruciate ligament (ACL) is an important structure in the knee. The ACL does not heal following lesions, and surgical reconstruction is the standard treatment among athletes.
Arliani, Gustavo, Astur, DC, Cohen,, Golano,, Jalikjian,, Kaleka,, Moraes,   +6 more
core   +2 more sources