Results 41 to 50 of about 366 (127)

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, Volume 13, Issue 41, 22 July 2026.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

Localized nodular synovitis of the infrapatellar fat pad

Indian Journal of Orthopaedics, 2013
We report a case of localized nodular synovitis of the infrapatellar fat pad impinging on the patellofemoral joint causing limitation of extension. Arthroscopy involved use of a superolateral portal because location of lesion hindered access via a conventional anterior portal.
Park, Jong-Hoon, Ro, Kyung-Han, Lee, Dae-Hee   +2 more
openaire   +3 more sources

An emerging player in knee osteoarthritis: the infrapatellar fat pad [PDF]

Arthritis Research & Therapy, 2013
The role of inflammation in the development, progression, and clinical features of osteoarthritis has become an area of intense research in recent years. This led to the recognition of synovitis as an important source of inflammation in the joint and indicated that synovitis is intimately associated with pain and osteoarthritis progression.
Ioan-Facsinay, A., Kloppenburg, M.
openaire   +3 more sources

Osteoarthritis: Epidemiology, Diagnosis, and Treatment

MedComm, Volume 7, Issue 7, July 2026.
Osteoarthritis (OA) is a multifactorial degenerative joint disease and a leading cause of disability worldwide. This graphical abstract summarizes the epidemiology, diagnostic strategies, and therapeutic approaches of OA. OA development is driven by aging, metabolic dysregulation, and mechanical stress, leading to progressive joint degeneration ...
Qin Ru, Dongliang Yuan, Shide Jiang, Xiaoxuan Zhao, Xu Liu, Yusheng Li, Shuguang Liu, Yuxiang Wu   +7 more
wiley   +1 more source

Evaluation, Treatment, and Rehabilitation Implications of the Infrapatellar Fat Pad [PDF]

Sports Health: A Multidisciplinary Approach, 2015
Context: The infrapatellar fat pad (IFP) is in the anterior knee compartment and may be a major pain generator. Evidence Acquisition: A PubMed database search using the terms Hoffas fat pad, anterior interval, and infrapatellar fat pad
Hannon, Joseph, Bardenett, Sean, Singleton, Steven, Garrison, J. Craig   +3 more
openaire   +2 more sources

Modified Tibial Plateau Levelling Osteotomy in a Cat With a Cranial Cruciate Ligament Rupture and a Concurrent Medial Patellar Luxation

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
A 12‐year‐old castrated male Russian Blue cat presented with cranial cruciate ligament rupture and concurrent grade 3 medial patellar luxation. A modified tibial plateau‐levelling osteotomy (mTPLO) using an Arix‐vet plate with a 2‐mm offset was performed, simultaneously correcting cranial tibial thrust and patellar luxation in a single procedure.
Ji‐Hwan Pahk, Kyu‐Won Kang, Byung‐Jae Kang   +2 more
wiley   +1 more source

Function of the Infrapatellar Fat Pad and Advanced Hoffa's Disease With Ossification

The Turkish Journal of Gastroenterology, 2014
Being one of the conditions presenting with patellar pain, Hoffa's syndrome is characterized with inflammation of the fat tissue in the patellar region.
Murat KARKUCAK, Erhan ÇAPKIN, İpek CAN, Avni Mustafa ÖNDER, Ali KÜPELİ3   +4 more
doaj  

Characterization of the Ligamentum Mucosum in the Feline and Canine Stifle

Anatomia, Histologia, Embryologia, Volume 55, Issue 4, July 2026.
ABSTRACT In humans, the ligamentum mucosum (LM) is described as a ligamentous structure originating from the femoral intercondylar notch and inserting into the infrapatellar fat pad. Proposed clinical implications include knee stabilization, contribution to post‐operative revascularization of adjacent structures, and causation of anterior knee pain if ...
Nathan Thomas Ko, Elizabeth Moran Woodward   +1 more
wiley   +1 more source

Correlation analysis between the mDIXON-quant fat quantification parameters of the infrapatellar fat pad and the severity of knee osteoarthritis

Journal of Orthopaedic Surgery and Research
Purpose This study aimed to explore the correlation between the proton density fat fraction (PDFF) of the infrapatellar fat pad and the severity of knee osteoarthritis (KOA), with a focus on identifying potential imaging biomarkers for KOA progression ...
Bao-Gen Zhao, Yu-Jin Zhang, Meng Wang, Ning Wang, Yong Wang, Ting Gao, Li Zhang   +6 more
doaj   +1 more source

Serum Leptin Exacerbates Osteoarthritis by Promoting Subchondral Bone H‐Type Vessel Angiogenesis via Activation of the PI3K/AKT Pathway

Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT Osteoarthritis (OA) is a common degenerative joint disease closely associated with obesity. Adipokines secreted by adipose tissue play critical roles in disease progression. This study focuses on the adipokine leptin and investigates its relationship with knee osteoarthritis.
Ruifu Li, Zhao Xi, Shitong Luo, Jun Qin, Tao Liu, Jian Zhang   +5 more
wiley   +1 more source