Results 211 to 220 of about 20,436 (308)

Pharmacokinetics, Pharmacodynamics, Efficacy and Drug Resistance Selection of Injectable Long‐Acting Lenacapavir Pre‐Exposure Prophylaxis (PrEP) Against HIV

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 5, May 2026.
ABSTRACT Oral pre‐exposure prophylaxis (PrEP) can substantially reduce HIV infection risk when taken as prescribed. However, many individuals struggle adhering to the daily regimen. Twice‐yearly injections of the novel HIV capsid inhibitor lenacapavir (LEN) demonstrated potential in recent PrEP trials.
Hee‐yeong Kim, Antonia Liebenberg, Lanxin Zhang, Max von Kleist   +3 more
wiley   +1 more source

Hypertransaminasemia in non-cirrhotic critically-ill patients. [PDF]

World J Hepatol
Fiore M, Cosenza G, Coppolino F, Pota V, Sansone P, Petrou S, Pace MC.   +6 more
europepmc   +1 more source

Enteric Nervous System Damage by Food Contaminants: A Pathway to Neurodegeneration?

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT The enteric nervous system (ENS), a key component of the gut–brain axis, has emerged as a critical player in the pathogenesis of Parkinson's disease (PD). It is the first neural system exposed to food contaminants (FCs)—a diverse group of ubiquitous toxic compounds fortuitously present in food derived from production, processing, storage, or ...
Helena Ramos, Ana Margarida Araújo, Isabel M. P. L. V. O. Ferreira, Miguel A. Faria   +3 more
wiley   +1 more source

Incidence and factors associated with central line-associated bloodstream infection in patients with chronic intestinal failure. A 20-year retrolective cohort. [PDF]

PLoS One
González-Salazar LE, Verdeja-Padilla PA, Reyes-Ramírez AL, Flores-López A, Castillo-Martínez L, Galindo-Fraga A, Chávez-Ríos AR, Huertas-Jiménez MA, Serralde-Zúñiga AE.   +8 more
europepmc   +1 more source

Peri‐operative pain management in major lower extremity amputation in vascular Surgery: a UK anaesthetic and vascular surgery Delphi consensus study*

Anaesthesia, Volume 81, Issue 5, Page 664-674, May 2026.
Summary Introduction Major lower extremity amputations occurring secondary to vascular disease remain prevalent worldwide. Pain surrounding these procedures is complex, multifactorial and associated with poor functional and psychosocial outcomes. The evidence base informing pain management approaches in major lower extremity amputations remain largely ...
Thanapon Ekkunagul, Caitlin Sara MacLeod, Anna Celnik, John Chalmers, Ross Thomson, Alan J. R. Macfarlane, David Bosanquet, John Nagy, Patrice Forget, the Delphi expert panel, Abhijoy Chakladar, Ahmed Abidia, Alan Fayaz, Alan Macfarlane, Alasdair Taylor, Alastair Thomson, Alexander Bell, Amy Sadler, Andrea Harvey, Andrew Mitchell, Andrew Tambyraja, Andrew William Garnham, Andrey Varvinskiy, Ankur Thapar, Anna Celnik, Caroline Curry, Catherine Western, Catriona Semple, Christopher G Davies, Craig Forrest, David Bosanquet, Denis Harkin, Diane Rosemary Hildebrand, Douglas James MacKenzie, Emma Elizabeth Florence Scott, Emma Jannine Baird, Ferdinand Serracino‐Inglott, Fiona Myint, Frances Kent, Francesco Torella, Gareth Harrison, George A. Antoniou, George Edward Smith, Graeme A McLeod, Ian Chetter, Indran Raju, John Chalmers, John Nagy, John O'Donoghue, Jonathan Paul Seeley, Kaji Sritharan, Keith Hussey, Keith Jones, Kersten Morgan Bates, Kevin Graham Mercer, Kieran Murphy, Lisa Anne Grimes, Matt Metcalfe, Maureen Sweeney, Michael McCusker, Michael Neil, Michelle Lamont, Mohamed Elsherif, Nat Haslam, Naveeta Maini, Nicholas Stuart Greaves, Patrick Coughlin, Patrice Forget, Peter Merjavy, Robert Hinchliffe, Rob Sayers, Ross Thomson, Russell William Jamieson, Sachin R Kulkarni, Sandeep Bahia, Sandip Nandhra, Serena Goon, Tanim Siddiqui, Tim Stansfield, Vanessa Fludder, Vikas Kaura, Vishal Gupta   +81 more
wiley   +1 more source

Recurrent Bloodstream Infections Without Sepsis in a Patient With Short Bowel Syndrome on Parenteral Nutrition: A Case of Potential Sepsis Tolerance. [PDF]

Cureus
Brin A, Israel S, Matza-Porges S, Ackerman Z.   +3 more
europepmc   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Outpatient Parenteral Antimicrobial Therapy (OPAT) in Italy: A Scoping Review. [PDF]

Infect Dis Ther
Moreal C, Giuliano S, Prataviera F, Fantoni M, Mezzadri S, Menozzi V, Marin M, Cetatean R, Sora E, Del Turco ER, Tumietto F, Moracas C, Guarino A, Vecchio R, Odone A, Urbančič V, Palese A, Tascini C.   +17 more
europepmc   +1 more source

Mechanism of Cardiac Arrest in Fatal Anaphylaxis

Clinical &Experimental Allergy, Volume 56, Issue 5, Page 506-515, May 2026.
This population‐based retrospective cohort study of clinical deterioration in anaphylaxis deaths identifies bronchospasm as the preponderant cause of cardiac arrest, especially in food and drug allergen exposures. The clinical implication is that anaphylaxis guidelines require appropriate emphasis on respiratory involvement and treatment to prevent ...
Ben A. McKenzie, Stuart D. Marshall, Lena A. Sanci, Catriona Moynihan, Chris Selman, Jo A. Douglass   +5 more
wiley   +1 more source

Conceptual and operational consistency in defining intestinal failure across randomized controlled trials: a systematic review and meta-research analysis. [PDF]

BMC Gastroenterol
Montoya-Quintero KF, Valencia S, Pérez MCF, Visconti-Lopez FJ, Marín-Hamburguer Y, Lozada-Martinez ID.   +5 more
europepmc   +1 more source