Results 111 to 120 of about 98,970 (350)
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Materiales de Construccion, 2018 Cracks in reinforced concrete elements can cause major durability issues due do the accelerated ingress of aggressive substances. In this study, repair of cracks was addressed by incorporating encapsulated polyurethane based healing agents in the ...
B. Van Belleghem +2 more
doaj +1 more source
Influence of invasive crayfish on fine sediment transport, ingress and bed storage in lowland rivers [PDF]
, 2022 Kate L. Mathers +3 more
openalex +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Phenomenology of Graphite Burning in Air Ingress Accidents of HTRs
Science and Technology of Nuclear Installations, 2011 Air ingress with graphite burning belongs to the accident scenarios in HTRs with potentially severe consequences. This paper gives an overview of basic phenomena of graphite burning like ignition conditions and moving reaction fronts.
Rainer Moormann
doaj +1 more source
Crumbs complex-directed apical membrane dynamics in epithelial cell ingression [PDF]
, 2022 Sérgio Simões +10 more
openalex +1 more source