Results 91 to 100 of about 98,970 (350)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Simulation of lumbar and neck angle flexion while ingress of paratransit (angkot) in Indonesia as a preliminary design study

Journal of Mechatronics, Electrical Power, and Vehicular Technology, 2017
This is the preliminary finding of a study to simulate lumbar and neck flexion while ingress to the paratransit. The result of simulation will determine design aspect criteria as a preliminary step before ideation and implementation design steps ...
Yukhi Mustaqim Kusuma Sya’bana, Kadek Heri Sanjaya, Muhammad Redho Kurnia, James Shippen   +3 more
doaj   +1 more source

Eclipse Timings of the Transient Low Mass X-ray Binary EXO0748-676. IV. The Rossi X-Ray Timing Explorer Eclipses

, 2009
We report our complete database of X-ray eclipse timings of the low mass X-ray binary EXO0748-676 observed by the Rossi X-Ray Timing Explorer (RXTE) satellite.
Bevington, Hall, Hertz, Jahoda, Jahoda, Kent S. Wood, Koen, Lanza, Lewin, Maeda, Michael T. Wolff, Paul L. Hertz, Paul S. Ray, Porquet, Rots, Sakano, Simon, Soderhjelm, Wachter, Wolff, Wolff   +20 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

GPR Raw-Data Order Statistic Filtering and Split-Spectrum Processing to Detect Moisture

Remote Sensing, 2014
Considerable research into the area of bridge health monitoring has been undertaken; however, information is still lacking on the effects of certain defects, such as moisture ingress, on the results of ground penetrating radar (GPR) surveying.
Gokhan Kilic
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Mechanical Performance and Chloride Diffusivity of Cracked RC Specimens Exposed to Freeze-Thaw Cycles and Intermittent Immersion in Seawater

Advances in Materials Science and Engineering, 2016
The effects of crack width on chloride ingress and mechanical behavior of reinforced concrete (RC) specimens were experimentally studied after exposure to 300 cycles of freeze-thaw and seawater immersion (75 times).
Bei Shen, Yinghua Ye, Bo Diao, Xiaoning Zheng   +3 more
doaj   +1 more source

Multifactorial Chloride Ingress Model for Reinforced Concrete Structures Subjected to Unsaturated Conditions [PDF]

, 2022
Enrico Zacchei, Emilio Bastidas‐Arteaga   +1 more
openalex   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The effect of hydrophobic (silane) treatment on concrete durability characteristics

MATEC Web of Conferences, 2018
Hydrophobic (silane) impregnation represents a cost-effective way to increase the durability of concrete structures in cases where insufficient design cover quality and depth have been achieved.
Sohawon Haris, Beushausen Hans
doaj   +1 more source