Results 61 to 70 of about 30,063 (226)
Harnessing the Folding of Antitumor Peptides for Controlled Carrier‐Free Drug Delivery
Small, EarlyView.A disulfide‐bridged stapled p53 α‐helix co‐assembled with doxorubicin into protease‐resistant nanocomplexes. Reductive intracellular conditions induced helix refolding and nanostructure disassembly, which enabled the coordinated release of the chemotherapeutic agent and anticancer peptide.
Jae Yun Lee +9 more
wiley +1 more source
Beilstein Journal of Nanotechnology, 2016 This paper describes the synthesis and application of alginate–chitosan–cyclodextrin micro- and nanoparticulate systems loaded with isoniazid (INH) and isoconazole nitrate (ISN) as antimycobacterial compounds.
Albert Ivancic +5 more
doaj +1 more source
Andrology, EarlyView.ABSTRACT Background Erectile dysfunction (ED) secondary to cavernous nerve injury (CNI), such as that occurring after radical prostatectomy, remains a significant clinical challenge, particularly among patients who do not respond to phosphodiesterase Type 5 inhibitors (PDE5i).
Minh Nhat Vo +6 more
wiley +1 more source
Spore display using Bacillus thuringiensis exosporium protein InhA
, 2009 A new spore display method is presented that enables recombinant proteins to be displayed on the surface of Bacillus spores via fusion with InhA, an exosporium component of Bacillus thuringiensis.
Soo Keun Choi +9 more
core +1 more source
RNA-seq data on bmp15-/- vs. control (bmp15+/+;inha+/+).
, 2023 RNA-seq data on bmp15-/- vs. control (bmp15+/+;inha+/+).
Xin Zhang (35492) +7 more
core +1 more source
Towards a new tuberculosis drug: pyridomycin – nature's isoniazid
EMBO Molecular Medicine, 2012 Tuberculosis, a global threat to public health, is becoming untreatable due to widespread drug resistance to frontline drugs such as the InhA‐inhibitor isoniazid.
Ruben C. Hartkoorn +9 more
doaj +1 more source
Scale Versus Technology—M&A Effects by Firm Size and Ex‐Post M&A Time Horizon in Korea
Asian-Pacific Economic Literature, EarlyView.ABSTRACT This study aims to examine the effects of mergers and acquisitions (M&A) on technical change (TC) and the scale component (SC)—the two primary constituents of total factor productivity (TFP)—by firm size and ex‐post M&A time horizon (i.e., short‐term vs. long‐term effects).
Sinwoo Lee +4 more
wiley +1 more source
Exploring the plasticity of the InhA substrate-binding site using new diaryl ether inhibitors
International audienceTuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a worldwide scourge with more than 10 million people affected yearly. Among the proteins essential for the survival of Mtb, InhA has been and is still clinically
Rodriguez, Frédéric +21 more
core +2 more sources
Tropical Medicine &International Health, EarlyView.ABSTRACT Tuberculosis remains a major public health threat globally, with drug‐resistant strains undermining treatment efficacy. We analyzed 126 Mycobacterium tuberculosis (M. tuberculosis) isolates with diverse drug resistance spectra and selected 35 for whole genome sequencing (WGS) using Illumina NextSeq, SMRT PacBio Onso and SMRT PacBio Revio ...
Unarine Matodzi +5 more
wiley +1 more source