Results 1 to 10 of about 8,860 (214)
Biochemistry and Biophysics ReportsMycobacterium tuberculosis catalase-peroxidase (Mt-KatG) is a bifunctional heme-dependent enzyme that has been shown to activate isoniazid (INH), the widely used antibiotic against tuberculosis (TB).
Adelaida Díaz Vilchis +2 more
exaly +4 more sources
Immunogenicity assay of KatG protein from Mycobacterium tuberculosis in mice: preliminary screening of TB vaccine [PDF]
The Ukrainian Biochemical Journal, 2018 The tuberculosis (TB) disease is still widely found even though BCG vaccine given to many people. Ineffectiveness of the BCG vaccine is one of causes that make the difficulties in preventing TB transmission. Objective of the research was to determine the
P. Purkan +4 more
doaj +4 more sources
Two Novel katG Mutations Conferring Isoniazid Resistance in Mycobacterium tuberculosis [PDF]
Frontiers in Microbiology, 2020 Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis, is among the top 10 leading causes of death worldwide. The treatment course for TB is challenging; it requires antibiotic administration for at least 6 months, and bacterial ...
Li-Yu Hsu +13 more
doaj +3 more sources
Journal of Pure and Applied Microbiology, 2021 Resistance to antimycobacterial agents consistently remains a major obstacle to end TB in India. Geographical prevalence data regarding drug-resistant evolutionary genetics of M. tuberculosis (MTB) remains sparse in India. Our objective was to determine
Neetha S Murthy +8 more
doaj +1 more source
Isoniazid resistance-conferring mutations are associated with highly variable phenotypic resistance
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2023 Background: High-dose isoniazid is recommended in the 9–12 months short-course regimen for multidrug-resistant tuberculosis with inhA mutation. However, there is insufficient evidence to support the assumption of genotypic-phenotypic concordance.
Senamile Lale Ngema +9 more
doaj +1 more source
Gut Microbes, 2022 This study investigates the interplay between Lon protease and catalase-peroxidase (KatG) in relation to virulence modulation and the response to oxidative stress in Salmonella Typhimurium (ST).
Perumalraja Kirthika +3 more
doaj +1 more source
International Journal of Infectious Diseases, 2022 Purpose: Indonesia is ranked as the fifth highest case of MDR TB in the world. MDR TB occurs due to resistance to Rifampicin and INH drugs caused by mutations in the M.Tb gene.
A. Fathurrachman +2 more
doaj +1 more source
Pattern of InhA and KatG mutations in isoniazid monoresistant Mycobacterium tuberculosis isolates
Lung India, 2020 Aims and Objectives: The aim of the study is to detect the pattern of genetic mutation, i.e., Inh A or Kat G or both (Inh A and kat G) in isoniazid (INH) monoresistant mycobacteria and to correlate with the pattern in multidrug-resistant (MDR) isolates ...
Ashok Singh Charan +6 more
doaj +1 more source
Mutation of katG in a clinical isolate of Mycobacterium tuberculosis: effects on catalase-peroxidase for isoniazid activation [PDF]
The Ukrainian Biochemical Journal, 2016 Mutations in katG gene are often associated with isoniazid (INH) resistance in Mycobacterium tuberculosis strain. This research was perfomed to identify the katG mutation in clinical isolate (L8) that is resistant to INH at 1 μg/ml.
Purkan, +5 more
doaj +1 more source
Journal of Pure and Applied Microbiology, 2019 Anti-tubercular therapy is one of the effective strategies used to control tuberculosis, so, a planned and accurate treatment regimen is of utmost importance, but number of cases are being treated as MDR on the basis of rifampicin mono resistance.
Sana Nudrat, Umar Farooq, Mazhar Maqsood
doaj +1 more source