Results 21 to 30 of about 8,860 (214)

Large-scale genomic analysis of Mycobacterium tuberculosis reveals extent of target and compensatory mutations linked to multi-drug resistant tuberculosis

Scientific Reports, 2023
Resistance to isoniazid (INH) and rifampicin (RIF) first-line drugs in Mycobacterium tuberculosis (Mtb), together called multi-drug resistance, threatens tuberculosis control.
Gary Napier, Susana Campino, Jody E. Phelan, Taane G. Clark   +3 more
doaj   +1 more source

Three-Dimensional Model and Molecular Mechanism of Mycobacterium tuberculosis Catalase-Peroxidase (KatG) and Isoniazid-Resistant KatG Mutants [PDF]

Microbial Drug Resistance, 2004
Mycobacterium tuberculosis KatG enzyme functions both as catalase for removing hydrogen peroxide (H 2 O 2 ) and as peroxidase for oxidating isoniazid (INH) to active form of anti-tuberculosis drug. Although mutations in
L, Mo, W, Zhang, J, Wang, X H, Weng, S, Chen, L Y, Shao, M Y, Pang, Z W, Chen   +7 more
openaire   +2 more sources

Mutations in rpoB and katG genes of multidrug resistant mycobacterium tuberculosis undetectable using genotyping diagnostic methods

The Pan African Medical Journal, 2017
INTRODUCTION: Tuberculosis remains the leading causes of death worldwide with frequencies of mutations in rifampicin and isoniazid resistant Mycobacterium tuberculosis isolates varying according to geographical location.
Faustinos Tatenda Takawira, Racheal Shamiso Dube Mandishora, Zephaniah Dhlamini, Ellen Munemo, Babill Stray-Pedersen   +4 more
doaj   +1 more source

Catalase-peroxidases (KatG) Exhibit NADH Oxidase Activity [PDF]

Journal of Biological Chemistry, 2004
Catalase-peroxidases (KatG) produced by Burkholderia pseudomallei, Escherichia coli, and Mycobacterium tuberculosis catalyze the oxidation of NADH to form NAD+ and either H2O2 or superoxide radical depending on pH. The NADH oxidase reaction requires molecular oxygen, does not require hydrogen peroxide, is not inhibited by superoxide dismutase or ...
Rahul, Singh, Ben, Wiseman, Taweewat, Deemagarn, Lynda J, Donald, Harry W, Duckworth, Xavi, Carpena, Ignacio, Fita, Peter C, Loewen   +7 more
openaire   +2 more sources

Genetic diversity of clinical isolates of Mycobacterium tuberculosis in Northeast of Iran [PDF]

Reviews in Clinical Medicine
Background: Mycobacterium tuberculosis is still one of the most dangerous human pathogens. Identification of the relationships between different clinical strains has remained a high priority for epidemiology research. Methods: In this study, we used MLSA
Samaneh Saedi, kiarash ghazvini, Masoud Youssefi, Hadi Safdar, saman soleimanpour, Parviz Afrough, Amir Azimian, hamid solgi, Masoud Keikha   +8 more
doaj   +1 more source

concatenated_gyrA-gyrB-hsp65-katG-rpoB

, 2013
concatenated_gyrA-gyrB-hsp65-katG ...
Anis Karboul (413949), Namouchi, Amine, Mardassi, Helmi, Maria Cristina Gutierrez (354223), Amine Namouchi (105634), Gutierrez, Maria Cristina, Michel Fabre (107158), Fabre, Michel, Karboul, Anis, Helmi Mardassi (413950)   +9 more
core   +1 more source

Investigations on mutations in katG gene and inhA promoter region associated with isoniazid resistance in the clinical isolates of mycobacterium tuberculosis from Tehran, Iran

Chronic Diseases Journal
BACKGROUND: Isoniazid (INH) is one of the first-line drugs used for the treatment of Mycobacterium tuberculosis (Mtb). This study aimed to determine the mutations in katG and inhA promoter regions associated with INH resistance in clinical isolates of ...
Shahrzad Shafiei, Kambiz Davari, Sabah Hasani   +2 more
doaj   +1 more source

Molecular characterisation of mutations associated with resistance to first- and second-line drugs among Indonesian patients with tuberculosis

Journal of Taibah University Medical Sciences, 2020
الملخص: أهداف البحث: تهدف هذه الدراسة لتحديد الخصائص الجزيئية لتسلسل الجينات rpoB، katG، rrs وgyrA في السل الفطري التي تم عزلها من مجموعة من مرضى إندونيسيين يعانون من السل.
Faiqah F. Umar, PhD, Dirayah R. Husain, PhD, Mochammad M. Hatta, PhD, Rosdiana R. Natzir, PhD, Rizalinda S. Sjahril, PhD, Ressy R. Dwiyanti, PhD, Ade R. Junita, MD, Muhammad R. Primaguna, MD   +7 more
doaj   +1 more source

Presence of katG gene in resistant Mycobacterium tuberculosis. [PDF]

Journal of Clinical Pathology, 1996
It has been reported recently that isoniazid resistant strains of Mycobacterium tuberculosis have lost the katG gene which encodes the catalase-peroxidase enzyme. A 35 mer oligonucleotide probe specific for the katG gene of M tuberculosis, 3' end-labelled with digoxigenin, was constructed and hybridised with DNA extracted from 26 clinical isolates of M
M, Jaber, A, Rattan, R, Kumar
openaire   +2 more sources

Mutations in rpoB and katG genes and the inhA operon in multidrug-resistant Mycobacterium tuberculosis isolates from Zambia

Journal of Global Antimicrobial Resistance, 2020
Objectives: It is established that resistance to rifampicin (RIF) in 90% of RIF-resistant Mycobacterium tuberculosis isolates is attributable to point mutations in the rpoB gene, whilst 50–95% of M. tuberculosis resistance to isoniazid (INH) is caused by
Eddie S. Solo, Chie Nakajima, Trevor Kaile, Precious Bwalya, Grace Mbulo, Yukari Fukushima, Sylvia Chila, Nanthan Kapata, Yogendra Shah, Yasuhiko Suzuki   +9 more
doaj   +1 more source