Results 31 to 40 of about 8,860 (214)

Virulence of Mycobacterium tuberculosis after Acquisition of Isoniazid Resistance: Individual Nature of katG Mutants and the Possible Role of AhpC. [PDF]

PLoS ONE, 2016
In the last decade, there were 10 million new tuberculosis cases per year globally. Around 9.5% of these cases were caused by isoniazid resistant (INHr) Mycobacterium tuberculosis (Mtb) strains.
Luisa Maria Nieto R, Carolina Mehaffy, Elizabeth Creissen, JoLynn Troudt, Amber Troy, Helle Bielefeldt-Ohmann, Marcos Burgos, Angelo Izzo, Karen M Dobos   +8 more
doaj   +1 more source

First description of the katG gene deletion in a Mycobacterium tuberculosis clinical isolate and its impact on the mycobacterial fitness

International Journal of Medical Microbiology, 2021
Isoniazid (INH) is the cornerstone of the anti-tuberculosis regimens and emergence of Mycobacterium tuberculosis (Mtb) resistant strains is a major threat to our ability to control tuberculosis (TB) at global level.
Flavio De Maio, Antonella Cingolani, Delia Mercedes Bianco, Alessandro Salustri, Ivana Palucci, Maurizio Sanguinetti, Giovanni Delogu, Michela Sali   +7 more
doaj   +1 more source

Synthesis, antimycobacterial evaluation, and molecular docking study of 1,2,4-triazole derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Fifteen 1,2,4-triazole derivatives were synthesised in this study and their MIC values against Mycobacterium tuberculosis (Mtb) ranged from 2 to 32 μg/mL.
Meng-Yu Xia, Yu-Xiang Cai, Jun-Xian Chen, Xin Zhao, Hong-Mei Dong, Zai-Chang Yang   +5 more
doaj   +1 more source

Mycobacterial FurA is a negative regulator of catalase-peroxidase gene katG [PDF]

Molecular Microbiology, 2001
In several bacteria, the catalase–peroxidase gene katG is under positive control by oxyR, a transcriptional regulator of the peroxide stress response. The Mycobacterium tuberculosis genome also contains sequences corresponding to oxyR, but this gene has been inactivated in the tubercle bacillus because of the presence of multiple mutations and ...
Zahrt, Thomas C., Song, Jian, Siple, Jessica, Deretic, Vojo   +3 more
openaire   +3 more sources

Cell‐Based Micro/Nanorobots: From Living Carriers to Living Therapeutic Specialists

SmartBot, EarlyView.
Cell‐based micro/nanorobots integrate evolutionarily acquired biological intelligence with engineered capabilities, offering new opportunities for precision medicine in vivo. However, the complex physiological environments of different organs pose significant challenges to their clinical translation.
Junfeng Wu, Zhaoyu Zhang, Ke Xu, Enkuo Li, Yuting Cui, Yuting Zhou, Huanyu Zhou, Beipei Zhang, Shuai Jiang, Xiaodong Wang, Jialin Jiang, Lianqing Liu, Niandong Jiao   +12 more
wiley   +1 more source

Computational approach to understanding the mechanism of action of isoniazid, an anti-TB drug

International Journal of Mycobacteriology, 2014
Tuberculosis (TB) is an ancient disease caused by Mycobacterium tuberculosis (MTB), which remains a major cause for morbidity and mortality in several developing countries.
Lingaraja Jena, Pranita Waghmare, Supriya Kashikar, Satish Kumar, Bhaskar C Harinath   +4 more
doaj   +1 more source

Detection of genomic mutations in katG and rpoB genes among multidrug-resistant Mycobacterium tuberculosis isolates from Tehran, Iran

New Microbes and New Infections, 2021
Multidrug-resistant (MDR) Mycobacterium tuberculosis strains, defined as resistant to at least isoniazid and rifampin, have emerged as a major worldwide health threat. Spontaneous point mutations in various genes of M.
B. Motavaf, N. Keshavarz, F. Ghorbanian, S. Firuzabadi, F. Hosseini, S. Zaker Bostanabad   +5 more
doaj   +1 more source

Role of KatG in Francisella tularensis Susceptibility to Resazurin.

Proceedings of the West Virginia Academy of Science, 2023
The CDC classifies Francisella tularensis as a Category A bioterrorism agent. Due to the risk of potential release of antibiotic-resistant F. tularensis strains, new therapeutics against F. tularensis must be developed.  Resazomycins are resazurin (Rz)-based compounds that exhibit antimicrobial activity against F.
openaire   +1 more source

Physical characterization of katG, encoding catalase HPI of Escherichia coli [PDF]

Gene, 1987
The gene encoding the bifunctional catalase-peroxidase HPI from Escherichia coli was located on a 3.8-kb HindIII fragment of the Clarke and Carbon plasmid pLC36-19 using transposon Tn5 insertions. This fragment was subcloned into the HindIII site of pAT153 to create pBT22. The size of the insert was reduced by BAL 31 digestion of one end to an apparent
B L, Triggs-Raine, P C, Loewen
openaire   +2 more sources

Patterns of Drug Resistance, Drug Resistance Conferring Mutations and Genomic DNA Methylation Revealed in Mycobacterium tuberculosis From South Africa

Tropical Medicine &International Health, EarlyView.
ABSTRACT Tuberculosis remains a major public health threat globally, with drug‐resistant strains undermining treatment efficacy. We analyzed 126 Mycobacterium tuberculosis (M. tuberculosis) isolates with diverse drug resistance spectra and selected 35 for whole genome sequencing (WGS) using Illumina NextSeq, SMRT PacBio Onso and SMRT PacBio Revio ...
Unarine Matodzi, Awelani Mutshembele, Eric Mensah, Dillon Muzondiwa, Ndivhuho A. Makhado, Oleg N. Reva   +5 more
wiley   +1 more source