Results 51 to 60 of about 8,860 (214)

Evidence for Differential Binding of Isoniazid by Mycobacterium tuberculosis KatG and the Isoniazid-Resistant Mutant KatG(S315T)

, 2016
Isoniazid is a mainstay of antibiotic therapy for the treatment of tuberculosis, but its molecular mechanism of action is unclear. Previous investigators have hypothesized that isoniazid is a prodrug that requires in vivo activation by KatG, the catalase−
Nancy L. Wengenack (2950350), Smilja Todorovic (165616), Lian Yu (1281078), Frank Rusnak (2945907)   +3 more
core   +1 more source

Nucleotide sequence of katG, encoding catalase HPI of Escherichia coli [PDF]

Journal of Bacteriology, 1988
The gene katG, encoding catalase HPI of Escherichia coli, was sequenced, predicting a 726-amino-acid protein. The sequence was confirmed by identification of potential regulatory elements and amino acid sequencing of peptides. HPI shows no homology to other catalases. The distances between katG, metF, and ppc were defined.
B L, Triggs-Raine, B W, Doble, M R, Mulvey, P A, Sorby, P C, Loewen   +4 more
openaire   +2 more sources

Characterization of the Catalase-Peroxidase KatG from Burkholderia pseudomallei by Mass Spectrometry [PDF]

Journal of Biological Chemistry, 2003
The electron density maps of the catalase-peroxidase from Burkholderia pseudomallei (BpKatG) presented two unusual covalent modifications. A covalent structure linked the active site Trp111 with Tyr238 and Tyr238 with Met264, and the heme was modified, likely by a perhydroxy group added to the vinyl group on ring I.
Donald, Lynda J., Krokhin, Oleg V., Duckworth, Harry W., Wiseman, Ben, Deemagarn, Taweewat, Singh, Rahul, Switala, Jack, Carpena, Xavi, Fita, Ignacio, Loewen, Peter C.   +9 more
openaire   +3 more sources

Bacterial Contribution to Hydrogen Peroxide Decomposition in Lake Erie Cyanobacterial Harmful Algal Bloom Communities Is Dependent on Bloom Stage

Environmental Microbiology Reports, Volume 18, Issue 5, October 2026.
A seasonal time series metatranscriptome dataset suggests that neutralising hydrogen peroxide in Microcystis blooms requires a complex division of labour that is further complicated by seasonality and bloom development. ABSTRACT Cyanobacterial harmful algal blooms (cHABs) are expanding globally and often involve toxin‐producing species such as ...
Chelsea E. Donovan, Gabriel Padilla, Madison Ashbaugh, Sophie Bencivenga, Jordan Cibellis, Wilson Ritterpusch, Cameron Tierney, Justin D. Chaffin, Louie L. Wurch, Morgan M. Steffen   +9 more
wiley   +1 more source

Role of the Met−Tyr−Trp Cross-Link in Mycobacterium tuberculosis Catalase-Peroxidase (KatG) As Revealed by KatG(M255I)^†

, 2016
Catalase-peroxidases (KatGs) are bifunctional enzymes possessing both catalase and peroxidase activities. Four crystal structures of different KatGs revealed the presence of a novel Met−Tyr−Trp cross-link which has been suggested to impart catalatic ...
Reza A. Ghiladi (1321260), Paul R. Ortiz de Montellano (2091886), Katalin F. Medzihradszky (24769)   +2 more
core   +1 more source

Computation‐Guided Tunnel Engineering Enhances O2 Transport and H2O2 Resistance of Fe(II)/α‐Ketoglutarate‐Dependent Dioxygenases

Advanced Science, Volume 13, Issue 53, 24 September 2026.
This study presents a computational tunnel engineering strategy in Fe(II)/α‐ketoglutarate‐dependent dioxygenases (αKGDs) to enhance oxygen (O2) transport, an essential molecule for αKGDs, and limit hydrogen peroxide (H2O2) entry, an inhibitor from the αKG supply system.
Huan Liu, Lunjie Wu, Liying Mao, Songyin Zhao, Hu Liu, Shiyi Xin, Donglin Zhao, Jie Gu, Yan Xu, Xinye Wang, Yao Nie   +10 more
wiley   +1 more source

In vitro modeling of isoniazid resistance mechanisms in Mycobacterium tuberculosis H37Rv

Frontiers in Microbiology, 2023
IntroductionMycobacterium tuberculosis (MTB), the causative agent of tuberculosis, has been a global threat to human beings for several decades. Treating tuberculosis has become more difficult as the prevalence of drug-resistant tuberculosis has ...
Thanadon Dokrungkoon, Orawan Tulyaprawat, Kamol Suwannakarn, Popchai Ngamskulrungroj   +3 more
doaj   +1 more source

UJI IMUNOGENISITAS PROTEIN KatG Mycobacterium tuberculosis ISOLAT KLINIS R SEBAGAI KANDIDAT VAKSIN TB [PDF]

, 2017
Ketidaksesuaian jenis strain mikroba merupakan faktor utama penyebab ketidakefektifan vaksin BCG dalam menekan infeksi TB. Penelitian ini bertujuan untuk mengetahui imunogenesitas protein KatG dari Mycobacterium tuberculosis klinis isolat R sebagai ...
RATNO BUDIYANTO, 081424253001
core   +1 more source

A switch and a failsafe: KatG’s mechanism for preservation of catalase activity using a conformationally dynamic Arg and an active-site Trp

Frontiers in Chemical Biology
Many novel structural features impart a robust catalase activity to KatG that is absent from all other members of its superfamily. The conformationally dynamic “Arg switch” and oxidizable “proximal Trp” have both figured prominently in investigations of ...
Hui Xu, Jessica R. Kenneson, Laura E. Minton, Douglas C. Goodwin   +3 more
doaj   +1 more source

Design, Synthesis, Antimycobacterial Evaluation, and In Silico Investigation of Benzisothiazole‐Based Hydrazide Derivatives as Potential Anti‐Tuberculosis Agents

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
A novel series of benzisothiazole‐based hydrazide derivatives was designed, synthesized, and evaluated for antitubercular activity. Compound 8k emerged as the most potent candidate (MIC = 0.25 μg/mL) with a high selectivity index (SI = 42) and bactericidal activity. Molecular docking and 100 ns simulations identified InhA as the probable target.
Vivek Sharma, Arun Sharma, Ruchi Poria, Pardeep Kumar   +3 more
wiley   +1 more source