Results 71 to 80 of about 8,860 (214)

Analysis of Heme Structural Heterogeneity in Mycobacterium Tuberculosis Catalase-Peroxidase (Katg) [PDF]

, 2003
Mycobacterium tuberculosis catalase-peroxidase (KatG) is a heme enzyme considered important for virulence, which is also responsible for activation of the anti-tuberculosis pro-drug isoniazid.
Magliozzo, Richard S., Girotto, Stefania, Yu, Shengwei, Schelvis, Johannes, Chouchane, Salem, Kapetanaki, Sofia   +5 more
core   +1 more source

Genetic Landscape of NAT2 in the Moroccan Population: Implications for Isoniazid Pharmacogenetics in Tuberculosis

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT The NAT2 gene encodes N‐acetyltransferase 2, an enzyme critically involved in the biotransformation of numerous xenobiotics and aromatic amines, including isoniazid, a cornerstone drug in tuberculosis therapy. Genetic polymorphisms in NAT2 lead to variable acetylation rates, clinically categorized as poor, intermediate, or rapid metabolizer ...
Nada Benyahya, Mohsine‐Ali El‐Hamri, Jaber Lyahyai, Ilham Ratbi, Imane Cherkaoui, Zineb Rchiad, Abdelaziz Sefiani   +6 more
wiley   +1 more source

Caracterização molecular de estirpes de Mycobacterium tuberculosis resistentes à isoniazida e/ou rifampicina isoladas de amostras clínicas do estado de Santa Catarina [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em FarmáciaApesar dos avanços no desenvolvimento de antimicrobianos no século XX e início do século XXI, estima-se em 8,6 milhões o ...
Prim, Rodrigo Ivan
core  

The quorum sensing-dependent gene katG of Burkholderia glumae is important for protection from visible light

, 2009
Quorum sensing (QS) plays important roles in the pathogenicity of Burkholderia glumae, the causative agent of bacterial rice grain rot. We determined how QS is involved in catalase expression in B. glumae. The QS-defective mutant of B.
O Choi, H Kim, Y Kang, I Hwang, E Goo, N Kim, Jae Sun Moon, H Chun, J Kim   +8 more
core   +1 more source

Mutations of katG and inhA in MDR M. tuberculosis

Tuberculosis and Respiratory Diseases, 2007
Backgrounds: Mutations of katG and inhA (ORF and promoter) are known to be related to isoniazid (INH) resistance of Mycobacterium tuberculosis. Because reports on these mutations in Korean isolates are limited (i.e. only the frequency of katG codon 463 was evaluated.), we tried to know the kinds of mutations of two genes and their frequencies in INH ...
Hai Hua Lin, Hee-Youn Kim, Yeo-Jun Yun, Chan Geun Park, Bum-Joon Kim, Young-Gil Park, Yoon-Hoh Kook   +6 more
openaire   +1 more source

Advances in Research on the Anti‐Tuberculosis Effects of Active Components in Chinese Herbal Medicine

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
This review summarizes how active constituents derived from Chinese herbal medicine exert anti‐tuberculosis (TB) effects via immunomodulation, direct inhibition of pathogens, and antioxidant activity. This synergistic, multi‐pathway mechanism highlights their potential as promising therapeutic candidates and adjunctive treatments against drug‐resistant
Qianqian Zhang, Siqi Lin, Juan Liu, Huani Wu, Xiaodan Lin, Jiawen He, Qiaoyu Yang, Jiang Pi, Fen Yang   +8 more
wiley   +1 more source

Analysis of Tuberculosis Cases with a Different Range of Mutations in Pathogen Genes Associated with Resistance to Isoniazid and Rifampicin

Туберкулез и болезни лёгких
The objective: to analyze cases of tuberculosis with a different range of mutations in the M. tuberculosis genes associated with resistance to isoniazid and rifampicin, to determine prevalence of such mutations, clinical significance and molecular ...
T. Yu. Salina, T. I. Morozova
doaj   +1 more source

Forces Shaping Diversity of Hydrogen Peroxide Detoxification Potential in Ocean Microbial Ecosystems

Environmental Microbiology, Volume 28, Issue 6, June 2026.
Marine microbes which lack catalases, like Prochlorococcus, depend on ‘helpers’, like catalase‐positive Alteromonas, for hydrogen peroxide detoxification. Our results indicate diverse and distinct distributions of catalases (katG, katE and manganese catalase) among community members.
Hannah Goldberg, Sonya T. Dyhrman, Michelle A. DeMers, Rogier Braakman, Gwenn M. M. Hennon   +4 more
wiley   +1 more source

Mycobacterium tuberculosis Is Resistant to Isoniazid at a Slow Growth Rate by Single Nucleotide Polymorphisms in katG Codon Ser315. [PDF]

PLoS ONE, 2015
An important aim for improving TB treatment is to shorten the period of antibiotic therapy without increasing relapse rates or encouraging the development of antibiotic-resistant strains. In any M.
Rose E Jeeves, Alice A N Marriott, Steven T Pullan, Kim A Hatch, Jon C Allnutt, Irene Freire-Martin, Charlotte L Hendon-Dunn, Robert Watson, Adam A Witney, Richard H Tyler, Catherine Arnold, Philip D Marsh, Timothy D McHugh, Joanna Bacon   +13 more
doaj   +1 more source

Antibiotic Resistance in Mycobacterium Tuberculosis. Peroxidase Intermediate Bypass Causes Poor Isoniazid Activation by the S315G Mutant of M. Tuberculosis Catalase-Peroxidase (Katg) [PDF]

, 2009
KatG (catalase-peroxidase) in Mycobacterium tuberculosis is responsible for activation of isoniazid (INH), a pro-drug used to treat tuberculosis infections.
Magliozzo, Richard S., Schelvis, Johannes, Suarez, Javier, Ranguelova, Kalina   +3 more
core   +1 more source