Results 91 to 100 of about 8,860 (214)

Genetic mechanisms of co-emergence of INH-resistant Mycobacterium tuberculosis strains during the standard course of antituberculosis therapy

Microbiology Spectrum
The incidence of isoniazid (INH) resistant Mycobacterium tuberculosis is increasing globally. This study aimed to identify the molecular mechanisms behind the development of INH resistance in M.
Ketema Tafess, Timothy Ting-Leung Ng, Kingsley King-Gee Tam, Kenneth Siu-Sing Leung, Jake Siu-Lun Leung, Lam-Kwong Lee, Hiu Yin Lao, Chloe Toi-Mei Chan, Wing-Cheong Yam, Samson Sai Yin Wong, Terrence Chi-Kwong Lau, Gilman Kit-Hang Siu   +11 more
doaj   +1 more source

Molecular characterization of Mycobacterium tuberculosis strains resistant to isoniazid

International Journal of Mycobacteriology, 2016
Objective/background: Tuberculosis is a major public health problem and the emergence of drug resistance complicates the situation even more. It is therefore crucial to implement all conclusions from the studies that aim at a better understanding of the ...
Salma Smaoui, Mariem Siala, Sondes Hadj Fredj, Sana Kammoun, Chema Marouane, Salma Hachicha, Asma Ghorbel, Radhouane Gdoura, Leila Slim, Taieb Ben Messaoud, Férièle Messadi   +10 more
doaj   +1 more source

Double nucleotide polymorphisms within the katG gene.

, 2015
Double nucleotide polymorphisms within the katG gene in colonies isolated from slow growth (Culture INH69.3) and fast growth cultures (Culture INH23.3) after 12–13 MGT were identified by Sanger sequencing.
Robert Watson (412887), Kim A. Hatch (585179), Jon C. Allnutt (797795), Catherine Arnold (271598), Irene Freire-Martin (797796), Philip D. Marsh (115087), Rose E. Jeeves (585181), Adam A. Witney (230772), Steven T. Pullan (144601), Charlotte L. Hendon-Dunn (797797), Alice A. N. Marriott (797794), Richard H. Tyler (797798), Timothy D. McHugh (372721), Joanna Bacon (41305)   +13 more
core   +1 more source

Prevalence of gene mutations associated with isoniazid resistance in drug-resistant tuberculosis: a study from Limpopo, South Africa

The Journal of Medical Laboratory Science & Technology of South Africa
Background: The mechanisms involved in isoniazid (INH) resistance are complex, and determining the kind of INH resistance conferred is essential in shaping patient-tailored tuberculosis (TB) regimens and avoiding cross-resistance.
C. Premjith, P. Mangena, B. Muponda, K. G. Kaapu, M. R. Lekalakala-Mokaba, A. Premjith, I. Rukasha   +6 more
doaj   +1 more source

Cross‐linking of M. tuberculosis Catalase‐Peroxidase (KatG)

The FASEB Journal, 2008
The formation of inter and intra‐molecular cross‐links has been reported for many heme and metallo‐proteins that form endogenous radicals. M. tuberculosis catalase‐peroxidase (KatG) is a bifunctional enzyme in which tyrosyl and tryptophanyl radicals are known to be formed during turnover with
Javier Suarez, Kalina Ranguelova, Richard S Magliozzo   +2 more
openaire   +1 more source

Conformational Differences in Mycobacterium tuberculosis Catalase-Peroxidase KatG and Its S315T Mutant Revealed by Resonance Raman Spectroscopy^†

, 2016
KatG from Mycobacterium tuberculosis is a heme-containing catalase-peroxidase, which belongs to the class I peroxidases and is important for activation of the prodrug isoniazid (INH), a front-line antituberculosis drug.
Richard S. Magliozzo (204160), Stefania Girotto (272420), Johannes P. M. Schelvis (2259751), Sofia Kapetanaki (2947524), Salem Chouchane (2695969), Shengwei Yu (2289808)   +5 more
core   +1 more source

Is IQG-607 a Potential Metallodrug or Metallopro-Drug With a Defined Molecular Target in Mycobacterium tuberculosis?

Frontiers in Microbiology, 2018
The emergence of strains of Mycobacterium tuberculosis resistant to isoniazid (INH) has underscored the need for the development of new anti-tuberculosis agents.
Bruno L. Abbadi, Bruno L. Abbadi, Valnês da Silva Rodrigues-Junior, Adilio da Silva Dadda, Adilio da Silva Dadda, Kenia Pissinate, Anne D. Villela, Maria M. Campos, Maria M. Campos, Luiz G. de França Lopes, Cristiano V. Bizarro, Cristiano V. Bizarro, Pablo Machado, Pablo Machado, Eduardo H. S. Sousa, Luiz A. Basso, Luiz A. Basso, Luiz A. Basso   +17 more
doaj   +1 more source

Resonance Raman Spectroscopy of Compound II and Its Decay in Mycobacterium Tuberculosis Catalase-Peroxidase KatG and its Isoniazid Resistant Mutant S315T

, 2005
The reaction of Mycobacterium tuberculosis KatG and the mutant KatG(S315T) with two different organic peroxides is studied using resonance Raman spectroscopy.
Magliozzo, Richard S., Yu, Shengwei, Schelvis, Johannes, Kapetanaki, Sofia M., Chouchane, Salem   +4 more
core   +1 more source

The impact of combined gene mutations in inhA and ahpC genes on high levels of isoniazid resistance amongst katG non-315 in multidrug-resistant tuberculosis isolates from China

Emerging Microbes and Infections, 2018
Whole-genome sequencing was used to analyze the profiles of isoniazid (INH) resistance-related mutations among 188 multidrug-resistant strains of Mycobacterium tuberculosis (MDR-TB) and mono-INH-resistant isolates collected in a recent Chinese national ...
Liguo Liu, Fengting Jiang, Lihong Chen, Bing Zhao, Jie Dong, Lilian Sun, Yafang Zhu, Bo Liu, Yang Zhou, Jian Yang, Yanlin Zhao, Qi Jin, Xiaobing Zhang   +12 more
doaj   +1 more source

Superoxide Reactivity of KatG:  Insights into Isoniazid Resistance Pathways in TB

, 2016
To gain insight into the mechanism of INH activation by KatG and to understand how resistance is conferred by the single active-site point mutation of KatG(S315T), we have employed pulse radiolysis as the means to initiate a catalytic pathway capable of ...
Reza A. Ghiladi (1321260), Paul R. Ortiz de Montellano (2091886), Diane E. Cabelli (410860)   +2 more
core   +1 more source