Results 81 to 90 of about 8,860 (214)

Predictive identification and design of potent inhibitors targeting resistance-inducing candidate genes from E. coli whole-genome sequences

Frontiers in Bioinformatics
Introduction: This work utilizes predictive modeling in drug discovery to unravel potential candidate genes from Escherichia coli that are implicated in antimicrobial resistance; we subsequently target the gidB, MacB, and KatG genes with some compounds ...
Abdullahi Tunde Aborode, Neeraj Kumar, Christopher Busayo Olowosoke, Christopher Busayo Olowosoke, Tope Abraham Ibisanmi, Islamiyyah Ayoade, Islamiyyah Ayoade, Haruna Isiyaku Umar, Haruna Isiyaku Umar, Abdullahi Temitope Jamiu, Basit Bolarinwa, Zainab Olapade, Abidemi Ruth Idowu, Ibrahim O. Adelakun, Isreal Ayobami Onifade, Benjamin Akangbe, Modesta Abacheng, Odion O. Ikhimiukor, Aeshah A. Awaji, Ridwan Olamilekan Adesola   +19 more
doaj   +1 more source

Metabolic Flux Analysis Reveals Entner–Doudoroff Pathway Dominance in Heterotrophic Deep‐Sea Bacterial Isolates

Environmental Microbiology Reports, Volume 18, Issue 3, June 2026.
Four deep‐sea bacterial strains, isolated from sediments at the water depths of 1–10 km, exhibited diverse metabolic flux patterns in central carbon metabolism as well as differing antioxidative responses. ABSTRACT Deep‐sea microorganisms adapt to extreme conditions by diverse metabolic strategies, yet their intracellular carbon fluxes remain largely ...
Yuxue Yang, Yue Wu, Keni Ma, Yue Li, Junwei Cao, Yuli Wei, Ruilian Yao, Weichao Wu   +7 more
wiley   +1 more source

Genetic code expansion for chemosensing and chemical actuation of biological functions

Bulletin of the Korean Chemical Society, Volume 47, Issue 5, Page 617-635, May 2026.
Genetic code expansion (GCE) broadens the chemical repertoire for precise control of protein function in biological systems. This review highlights GCE‐based sensing and actuating systems that operate through selective interactions between noncanonical amino acids and chemical triggers.
Jieun Bae, Dong‐Hyun Kim, Minseob Koh
wiley   +1 more source

Transcriptional regulation of furA and katG upon oxidative stress in Mycobacterium smegmatis

, 2001
The DNA region upstream of katG in Mycobacterium smegmatis was cloned and sequenced. The furA gene, highly homologous to Mycobacterium tuberculosis furA, mapped in this region. The furA-katG organization appears to be conserved among several mycobacteria.
C. Sala, A. Milano, G. Riccardi, D. Ghisotti, F. Forti   +4 more
core   +2 more sources

Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis

Nature Communications
Drug-resistant strains of Mycobacterium tuberculosis are a major global health problem. Resistance to the front-line antibiotic isoniazid is often associated with mutations in the katG-encoded bifunctional catalase-peroxidase.
XinYue Wang, William J. Jowsey, Chen-Yi Cheung, Caitlan J. Smart, Hannah R. Klaus, Noon EJ Seeto, Natalie JE Waller, Michael T. Chrisp, Amanda L. Peterson, Boatema Ofori-Anyinam, Emily Strong, Brunda Nijagal, Nicholas P. West, Jason H. Yang, Peter C. Fineran, Gregory M. Cook, Simon A. Jackson, Matthew B. McNeil   +17 more
doaj   +1 more source

katG mutations in isoniazid-resistant strains of Mycobacterium tuberculosis are not infrequent

Antimicrobial Agents and Chemotherapy, 1996
In a recent article (7), we reported the results of mutational analysis of katG in isoniazid-resistant Mycobacterium tuberculosis strains and reached a number of conclusions, one of which was that variations in the katG gene of isoniazid-resistant isolates of M. tuberculosis are infrequent.?? New data from our laboratory indicate that this statement is
Victor, TC, Pretorius, GS, Felix, JV, Jordaan, AM, van Helden, PD, Eisenach, KD   +5 more
openaire   +2 more sources

Viable but Nonculturable State, a Survival Strategy for Salmonella in Aquatic Environments

Water and Environment Journal, Volume 40, Issue 2, Page 183-202, May 2026.
Transition of Salmonella from a culturable state to a viable but nonculturable state under various environmental stresses and current methods for detecting viable Salmonella in environmental samples. ABSTRACT In the relentless battle for survival, Salmonella has evolved mechanisms to withstand harsh conditions such as extreme temperatures, fluctuating ...
Sanelisiwe Thinasonke Duze, Musa Marimani, Katlego Mamabolo, Mrudula Patel   +3 more
wiley   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, Volume 15, Issue 14, 10 April 2026.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Regulation of Catalase-Peroxidase KatG Is OxyR Dependent and Fur Independent in Caulobacter crescentus

, 2011
Most organisms that grow in the presence of oxygen possess catalases and/or peroxidases, which are necessary for scavenging the H(2)O(2) produced by aerobic metabolism.
Valéria C. S. Italiani, Vânia S. Braz, ITALIANI, Valeria C. S., MARQUES, Marilis V., José F. da Silva Neto, BRAZ, Vania S., SILVA NETO, Jose F. da, Marilis V. Marques   +7 more
core   +1 more source

DETEKSI MUTASI GEN KATG MYCOBACTERIUM TUBERCULOSIS DENGAN METODE PCR (POLYMERASE CHAIN REACTION) - HIBRIDISASI DOT BLOT MENGGUNAKAN PELACAK OLIGONUKLEOTIDA BERTANDA 32 [PDF]

, 2013
Penanganan dan pengendalian penyakit tuberkulosis (TB), penyakit yang disebabkan kuman M. tuberculosis, menjadi semakin sulit dengan meningkatnya kasus resistensi kuman penyebab terhadap obat anti tuberkulosis (oat) sepertiisoniazid.
R., Maria Lina, Yasmon, Andi, Bela, Budiman, R, Maria Lina   +3 more
core   +3 more sources