Results 91 to 100 of about 17,483 (305)

Risk factor analysis for fast track protocol failure [PDF]

, 2013
Background: The introduction of fast-track treatment procedures following cardiac surgery has significantly shortened hospitalisation times in intensive care units (ICU).
Bingold, Tobias Michael, Huneke, Patrick, Kiessling, Arndt-Holger, Moritz, Anton, Reyher, Christian, Zierer, Andreas   +5 more
core   +1 more source

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

Advanced Science, EarlyView.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu, Yueyin Han, Bingbing Xie, Lili Zhu, Wenxiu Xu, Yinzhen Han, Yue Liao, Shuwei Gao, Dingyuan Jiang, Jing Geng, Zhen Li, Yinan Hu, Huaping Dai   +12 more
wiley   +1 more source

Effects of sevoflurane and desflurane on the nociceptive responses of substantia gelatinosa neurons in the rat spinal cord dorsal horn: An in vivo patch-clamp analysis

Molecular Pain, 2020
Background Volatile anesthetics suppress noxiously evoked activity in the spinal dorsal horn, which could contribute in part to analgesia, immobility. Modulation of excitatory and inhibitory synaptic transmission in substantia gelatinosa neurons could ...
Yosuke Inada, Yusuke Funai, Hiroyuki Yamasaki, Takashi Mori, Kiyonobu Nishikawa   +4 more
doaj   +1 more source

Comparison of dermal and inhalation routes of entry for organic chemicals [PDF]

The quantitative comparison of the chemical concentration inside the body as the result of a dermal exposure versus an inhalation exposure is useful for assessing human health risks and deciding on an appropriate protective posture.
Clewell, Harvey J., III, Jepson, Gary W., Mcdougal, James N.   +2 more
core   +1 more source

Nitrous Oxide: Mechanism of Its Antinociceptive Action [PDF]

, 1995
Nitrous oxide (N2O) is an anesthetic gas known to produce an analgesic effect at sub-anesthetic concentrations. This analgesic property of N2O can be clinically exploited in a broad range of conditions where pain relief is indicated.
Quock, Raymond M., Vaughn, Linda K.
core   +1 more source

Neuroprotective Properties of Xenon. [PDF]

, 2020
Xenon is a rare noble gas that was introduced into clinical practice more than 70 years ago. Xenon's clinical properties are predicated by its ability to fit into preformed cavities of macromolecules thereby altering their biological functions.
Laitio, Timo, Maze, Mervyn
core  

Como Funciona o Xénon: Mecanismos de Neuro e Cardioprotecção [PDF]

, 2014
INTRODUCTION: The Xenon, a noble gas, has anesthetics properties, associated with remarkable hemodynamic stability as well as cardioprotective, neuroprotective proprieties.
Andrade, L, Lourenço, A, Morais, R, Tavares, J   +3 more
core   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Comparative analysis of the effects of inhalational and intravenous anesthetics on hemodynamic variability and cardiovascular complications in patients undergoing general anesthesia – a review of current evidence

Journal of Education, Health and Sport
Background. Patient hemodynamic stability during general anesthesia is a crucial factor, managing which helps avoid many complications, especially cardiovascular ones. Intravenous and inhaled anesthetics affect the human body differently, have different
Sandra Drabik, Maja Gałuszka, Aleksandra Gałuszka, Kamila Krycia, Karolina Mazur, Karolina Różycka, Magdalena Mulawa, Emilia Piaszczyńska, Dominika Matacz, Adrianna Adamczyk   +9 more
doaj   +1 more source