Results 221 to 230 of about 17,483 (305)

Resolving Endoplasmic Reticulum‐Protein Misfolding Restores Corticosteroid Sensitivity in Experimental Models of Severe Asthma

Allergy, EarlyView.
This study investigates the role of ER stress in steroid resistance in severe asthma. Results from advanced 3D models of human bronchial epithelial cells, steroid‐resistant severe asthma mouse models, and human severe asthma sputum samples show that treatment with ICS in combination with the ER stress inhibitor 4‐PBA significantly enhances steroid ...
Prabuddha S. Pathinayake, Alexandra C. Brown, Nikhil T. Awatade, Philip M. Hansbro, Katherine J. Baines, Richard Y. Kim, Nathan W. Bartlett, Jay C. Horvat, Peter A. B. Wark   +8 more
wiley   +1 more source

The effect of intravenous anesthesia on postoperative cognitive function in patients undergoing painless gastroscopy: a meta-analysis. [PDF]

BMC Gastroenterol
Jia Z, Leng Y, Fan Y, Ji W, Zhou B, Tan Z.   +5 more
europepmc   +1 more source

Impact of different anesthetics on ischemia reperfusion injuries in patients undergoing hepatectomy: a network meta-analysis. [PDF]

Front Med (Lausanne)
Wang S, Tian F, Zhang R, Deng Z, Zhou L, Ren L, Wu F.   +6 more
europepmc   +1 more source

Mesenchymal Stem Cells From a Klinefelter Syndrome Patient: Functional Characterization and Therapeutic Implications

Andrology, EarlyView.
ABSTRACT Background Cell therapy, particularly those utilizing mesenchymal stem/stromal cells (MSCs), is gaining traction as a therapeutic option for regenerative treatment in patients with limited therapeutic options. Although the safety of MSC‐based interventions is well established, uncertainties remain regarding how genetic abnormalities and ...
Marzena Zychowicz, Wioletta Lech, Anna Figiel‐Dabrowska, Marta Kot, Magdalena Murzyn, Natalia Malawska, Barbara Pienkowska‐Grela, Zuzanna Sandowska‐Markiewicz, Iwona Ziolkowska‐Suchanek, Agnieszka Zimna, Tomasz Oldak, Natalia Rozwadowska, Anna Sarnowska   +12 more
wiley   +1 more source

Multi-omics analysis reveals sevoflurane exacerbates cognitive impairment in diabetic mice by disrupting lipid metabolism. [PDF]

Sci Rep
Liu X, Wang F, Liu C, Yu K, Wang Y, Zhao G.   +5 more
europepmc   +1 more source

Laparoscopically guided transversus abdominis plane block versus local wound infiltration analgesia in laparoscopic surgery for peritoneal endometriosis: A prospective randomized controlled double‐blinded LTAP‐trial

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
No statistically significant difference in the mean or median opioid consumption between laparoscopically guided transversus abdominis plane block (LTAP) and local wound infiltration analgesia (LWI) (control) analgesia for laparoscopic peritoneal endometriosis surgery.
Anna M. Terho, Terhi Puhto, Johanna Laru, Outi Uimari, Pasi Ohtonen, Tero Rautio, Sari Koivurova   +6 more
wiley   +1 more source

Good Practice in Postoperative and Procedural Pain Management 2nd Edition [PDF]

, 2012
CARTER, BERNIE, Curry, Joe, Howard, Richard, Jain, Anoo, Liossi, Christina, Morton, Neil, Rivett, Kate, Rose, Mary, Tyrell, Jennifer, Walker, Suellen, Williams, Glynn   +10 more
core  

Cholangiocarcinoma in a central bearded dragon (Pogona vitticeps): A case report

Australian Veterinary Journal, EarlyView.
Cholangiocarcinoma is an uncommon malignant epithelial tumour of the biliary tract in reptiles and is rarely reported in central bearded dragons (Pogona vitticeps). This case report describes a 7‐year‐old male central bearded dragon in which a nonspecific coelomic opacity was incidentally detected during a routine clinical examination.
M Mikiewicz, K Paździor‐Czapula, I Otrocka‐Domagała   +2 more
wiley   +1 more source

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, EarlyView.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

Brain Pathology, EarlyView.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña, Enric Vidal, Natalia Fernández‐Borges, Jorge M. Charco, Carlos M. Díaz‐Domínguez, Cristina Sampedro‐Torres‐Quevedo, Josu Galarza‐Ahumada, Eva Fernández‐Muñoz, Maitena San‐Juan‐Ansoleaga, Miguel Ángel Pérez‐Castro, Nuno Gonçalves‐Anjo, Patricia Piñeiro, Samanta Giler, Nora González‐Martín, Nuria L. Lorenzo, Africa Manero‐Azua, Guiomar Perez de Nanclares, Mariví Geijo, Manuel A. Sánchez‐Martín, Jesús R. Requena, Joaquín Castilla   +20 more
wiley   +1 more source