Results 241 to 250 of about 352,671 (284)

HOXA5 Suppresses NEK7‐Mediated Alveolar Epithelial Pyroptosis in Acute Lung Injury by Transcriptionally Inhibiting KAT2A

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Alveolar epithelial cell pyroptosis exacerbates inflammation and tissue damage by releasing inflammatory mediators, thereby promoting the development of acute lung injury (ALI). However, the fundamental mechanism underlying alveolar epithelial cell pyroptosis in ALI has not yet been elucidated. Lipopolysaccharide (LPS) was used to simulate ALI
Lei Wang   +5 more
wiley   +1 more source

Intranasal pH and Olfactory Function Among Healthy Adults

open access: yesThe Laryngoscope, EarlyView.
In this cross‐sectional study of 62 adults, olfactory cleft (OC) pH was lower than that over the respiratory mucosa (RM), with repeated testing resulting in more alkaline pH and olfactory testing having no effect. OC pH, but not RM pH, was negatively correlated with odor identification scores and predicted 18% of the variance in these scores.
Anna Kristina Hernandez   +7 more
wiley   +1 more source

Mechanisms of Improving Feeding Function With Capsaicin Following Local Anesthesia in Infant Pigs

open access: yesThe Laryngoscope, EarlyView.
With inferior alveolar nerve anesthetization, we found changes in some behavioral variables, as well as a decrease in bolus sizes and improved airway protection. This highlights the tradeoff between feeding efficiency and feeding safety. With capsaicin administration, some behavioral variables were returned to baseline values fully or partially, which ...
Chloe E. Edmonds   +8 more
wiley   +1 more source

Prospective Study of Long‐Term Outcomes and the Patient Experience With Superior Laryngeal Nerve Block for Chronic Cough

open access: yesThe Laryngoscope, EarlyView.
Prospective study from April 2021 to August 2024 of adult patients with refractory chronic cough undergoing SLN block. This prospective assessment indicates that nearly 2 in 3 refractory chronic cough patients respond positively at 2 weeks post injection, with around 50% of these initial improvers endorsing ongoing cough symptom improvement at 6–9 ...
Andrew T. Peachman   +5 more
wiley   +1 more source

Vocal Fold Scar Treatment via Controlled Dexamethasone Delivery With a Light‐Activatable Implant

open access: yesThe Laryngoscope, EarlyView.
A light‐activatable dexamethasone implant was employed for the treatment of vocal fold (VF) scarring in a rabbit model. The implant enables controlled, repeatable drug release via near‐infrared laser irradiation, improving biomechanics, vibratory function, and histological architecture at the injury site.
Denzel Ryan D. Cruz   +6 more
wiley   +1 more source

Injectable Self‐Polymerizing Hydrogel as Bone Filler for Bone Defect Treatment

open access: yesMacromolecular Bioscience, EarlyView.
This study presents a multifunctional composite as an innovative bone cement substitute. By combining silver–hydroxyapatite–polydopamine to form a dynamic redox system that accelerates free radical polymerization, the material achieves smooth injectability.
Xiaozhuo Wu   +4 more
wiley   +1 more source

Dietary Blueberry Supplementation Attenuates the Effects of an Ultra‐Processed Food Cafeteria Diet on Weight Gain and Metabolic Parameters, Enhancing Nutrigenomic Profiles in C57BL/6 Mice

open access: yesMolecular Nutrition &Food Research, EarlyView.
1. Experimental Design (left panel) • Icons: ∘ Three C57BL/6 mice groups ∘ Control group (Standard chow) ∘ Cafeteria diet (cookies, soda, sausage, condensed milk, chow) ∘ CAFD + Blueberry (CAFD + BB smoothie and pellets) • Group Labels: ∘ Control (C): Standard diet ∘ CAFD: Cafeteria diet + SD ∘ BB: CAFD + BB • Duration: 16 weeks • Arrow pointing to ...
Felipe Mateus Pellenz   +18 more
wiley   +1 more source

The Effect of Anti‐3‐Hydroxy‐3‐Methylglutaryl‐CoA Reductase (HMGCR) Human Autoantibodies on Muscle Regeneration in Mice

open access: yesMuscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Anti‐3‐hydroxy‐3‐methylglutaryl‐CoA reductase (HMGCR) autoantibodies (aAbs) are pathogenic in immune‐mediated necrotizing myopathy (IMNM), partly through complement activation. C5 inhibition did not restore muscle strength in mice or patients with overt IMNM, suggesting additional pathogenic mechanisms.
Sarah Julien   +6 more
wiley   +1 more source

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