Inhalable Hsa‐miR‐30a‐3p Liposomes Attenuate Pulmonary Fibrosis
The study explores inhalable hsa‐miR‐30a‐3p‐loaded liposomes as a treatment for bleomycin‐induced pulmonary fibrosis in mice. Hsa‐miR‐30a‐3p is electroporated into liposomes and formulated into a dry powder for inhalation. Delivered via dry powder inhalation, it improves pulmonary function, promotes myofibroblast de‐differentiation by targeting CNPY2 ...
Shuo Liu+14 more
wiley +1 more source
On the action potential as a propagating density pulse and the role of anesthetics [PDF]
The Hodgkin-Huxley model of nerve pulse propagation relies on ion currents through specific resistors called ion channels. We discuss a number of classical thermodynamic findings on nerves that are not contained in this classical theory. Particularly striking is the finding of reversible heat changes, thickness and phase changes of the membrane during ...
arxiv +1 more source
Regional Anesthesia: Advantages of Combined Use with General Anesthesia and Useful Tips for Improving Nerve Block Technique with Ultrasound Technology [PDF]
Regional anesthesia is not always performed independently, but rather is frequently employed as part of a general anesthesia technique. Thus, its procedures and usefulness should be considered in settings where general anesthesia is used. In this chapter,
Tsuchiya, Masahiko
core +2 more sources
ANESTHETIC, ANALGETIC, HYPNOTIC – ARE THE TERMS IMPORTANT?
The review is devoted to pharmacology of the general anesthesia in the light of current understanding of this event and as a medical technique. The discussion covers the classification of medications used for general anesthesia basing on action mechanisms
A. E. Karelov+2 more
doaj +1 more source
Selective lesioning of SuM glutamatergic neurons promoted the induction of and delayed emergence from sevoflurane anesthesia and increased sevoflurane sensitivity. Optogenetic stimulation of SuM glutamatergic neurons or the SuM‐MS projection promoted behavioral arousal and cortical activation under steady‐state sevoflurane anesthesia and reduced the ...
Jiayan Li+8 more
wiley +1 more source
The method of inhalation therapy with micro-doses of mixtures noble gases with oxygen [PDF]
In this research, we presented the method of inhalation therapy with noble gas micro-doses and results of clinical studies in hospital of Russian Academy of Sciences (RAS). We have designed a device that allows dosed injection of noble gas with a volume of about 2-4 ml with peroxide vapors into the nasal cavity.
arxiv
The thermodynamics of lipid ion channel formation in the absence and presence of anesthetics. BLM experiments and simulations [PDF]
It is known that lipid membranes become permeable in their melting regime. In microscopic conductance measurements on black lipid membranes one finds that conduction takes place via quantized events closely resembling those reported for protein ion channels. Here, we present data of ion currents through black lipid membranes in the presence and absence
arxiv +1 more source
ON OF AIR POLLUTION WITH INHALATION ANESTHETICS AND DISINFECTANTS IN OPERATING ROOMS
At present levels of air pollution with inhalation anesthetics and disinfectants in operating rooms as well as protection from their unfavorable effect on health and professional activities of the surgical personnel are underexplored.
N. A. Trekova+3 more
doaj +1 more source
Functional Polarization of Liver Macrophages by Glyco Gold Nanoparticles
Macrophages play a critical role in several pathophysiological diseases by being involved in the activation of adaptive and innate immune responses. The repolarization of macrophages using gold nanoparticles functionalized with glycans for a more selective targeting toward a restorative phenotype leads to an amelioration of the events.
Jennifer Fernandez Alarcon+25 more
wiley +1 more source
A type of polydopamine (PDA) nanogel decorated adhesive and responsive hierarchical microcarriers for ALA delivery and deafness prevention. PDA@microcarriers can protect the encapsulated drugs from external disturbances and prolong their retention time in the inner ear.
Hong Chen+8 more
wiley +1 more source