Results 221 to 230 of about 44,337 (260)

Safety, tolerability, pharmacokinetics and pharmacodynamics of the spleen tyrosine kinase inhibitor BI 894416 in healthy volunteers and patients with asthma

British Journal of Pharmacology, Volume 183, Issue 11, Page 2660-2674, June 2026.
Abstract Background and Purpose Spleen tyrosine kinase (SYK) has broad biological functions in inflammation and immunity. The orally administered SYK inhibitor BI 894416 was investigated in a single‐rising‐dose Phase I study in healthy volunteers and in a combined single‐ and multiple‐rising‐dose Phase Ib study in patients with mild asthma ...
Saskia Carstensen‐Aurèche, Tobias Litzenburger, Dorothy De Sousa, Reinhard Sailer, Ewald Benediktus, Denis Delic, Fabian Müller, Meike Müller, Jens M. Hohlfeld   +8 more
wiley   +1 more source

Real-world use of inhaled corticosteroid/formoterol as needed in adults with mild asthma: the PRIME study. [PDF]

ERJ Open Res
Brusselle G, Blasi F, Gessner C, Kuna P, Wark P, Cappellini G, Oosterom E, Van Der Deijl M, Bucchioni E, Topole E.   +9 more
europepmc   +1 more source

ACTH Stimulation Testing Is Often Unnecessary After Appropriate Patient Preparation Prior to Screening Cortisol Measurement

Clinical Endocrinology, Volume 104, Issue 6, Page 567-573, June 2026.
ABSTRACT Context Screening morning serum cortisol is used to select patients for ACTH stimulation testing to diagnose adrenal insufficiency (AI) but may be affected by pre‐analytical factors. Careful consideration to discontinue confounding medications beforehand may preclude the need for subsequent stimulation testing.
Christopher J. Symonds, Alexander A. Leung, Gregory A. Kline   +2 more
wiley   +1 more source

Maintenance of an Asthma Intervention Post-Trial: Use of a Patient-Activated Reliever-Triggered Inhaled Corticosteroid (PARTICS) Strategy in Black and Latinx Patients. [PDF]

J Am Board Fam Med
Cardet JC, Bailey JM, Hurley LP, Maher NE, Staton EW, Yawn BP, Zaeh SE, Israel E, other PREPARE investigators;, Apter AJ, Bradford P, Calderon-Candelario RA, Carroll JK, Chupp GL, Cohen R, Ericson B, Fuhlbrigge AL, Kaplan BM, Kruse JM, Nazario S, Pace WD, Pasarica M, Phipatanakul W, Riley IL, Rodriguez-Louis J, Shenoy K, Stranges PM, Tapp H, Wechsler ME.   +28 more
europepmc   +1 more source

Risk Factors for Pneumocystis Jirovecii Pneumonia Among Kidney Transplant Recipients in Southeast France: A 10 Years Case‐Control Study

Clinical Transplantation, Volume 40, Issue 6, June 2026.
ABSTRACT Background Pneumocystis jirovecii is an opportunistic fungus responsible for Pneumocystis pneumonia (PJP) in hosts with impaired cell‐mediated immunity, particularly solid organ transplant recipients. The aim of our study was to identify risk factors associated with PJP in kidney transplant recipients (KTRs).
Solenne Hulot, Raphaël Godefroy, Barbara Doudier, Léa Delorme, Sébastien Cortaredona, Catherine Sartor, Coralie L'Ollivier, Stéphane Burtey, Valérie Moal, Nadim Cassir   +9 more
wiley   +1 more source

Respiratory Biomarkers: An Opportunity for Patient‐Centric Microsampling Approach for Treatment Optimization

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
Overview of patient centric microsampling approach for monitoring respiratory biomarkers for treatment optimization. Image created in BioRender. Khan, A. (2026) https://BioRender.com/17jm5cs. ABSTRACT The clinical heterogeneity of respiratory disorders emphasizes the need for personalized approaches to prevention, diagnosis, and therapy.
Ahmar Khan, Jacqueline L. Stair, Daniel Baker, Neil Spooner, Darragh Murnane   +4 more
wiley   +1 more source

Epithelial-to-mesenchymal transition is an active process in the large airways of patients with asthma-COPD overlap and partially abrogated by inhaled corticosteroid treatment: a bronchoscopy endobronchial biopsy study. [PDF]

Front Immunol
Dey S, Lu W, Pathinayake PS, Waters M, Haug G, Larby J, Weber HC, Wark PAB, Eapen MS, Sohal SS.   +9 more
europepmc   +1 more source

Impact of Electronic Cigarette Use on the Oral Microbiota: A Systematic Review

Journal of Clinical Periodontology, Volume 53, Issue 6, Page 956-985, June 2026.
ABSTRACT Aim To examine whether the oral microbiota of e‐cigarette users differs from that of never smokers and current smokers. Materials and Methods PubMed, Scopus and Web of Science were searched on 27 August 2025. Human studies using molecular methods to compare oral microbiota in saliva, subgingival plaque and oral mucosal swabs among e‐cigarette ...
Giusy Rita Maria La Rosa, Lakshman Perera Samaranayake, Egija Zaura, Ang Sun, Virginia Fuochi, Pio Maria Furneri, Jan Kowalski, Karol Myszel, Iain Chapple, Riccardo Polosa   +9 more
wiley   +1 more source

Is using inhaled corticosteroid effective against COVID-19 pneumonia severity and mortality? [PDF]

Tuberk Toraks
Kiliç H, Argüder E, Civak M, Gemcioğlu E, Kaya Kalem A, Hasanoğlu İ, Kayaaslan B, Günay S, Akpinar E, Hezer H, Şeref Parlak EŞ, Sadi Aykan F, Kocaman Y, Ünsay Metan E, Er M, Dalkiran A, Çelenk Ergüden H, Hancioğlu Z, Altin E, Ceylan E, Eser F, Altunsoy Aypak A, Akinci E, Karaahmetoğlu S, Asfuroğlu Kalkan E, Inan O, Yilmaz A, Yüksel Güler B, Çopuroğlu E, Özkoçak Turan I, Demir E, Hayme S, Gökmen D, Surel AA, Ünsal E, Hasanoğlu HC, Ateş İ, Güner R, Karalezli A.   +38 more
europepmc   +1 more source

COPD Management in Primary Care: Underutilisation of Nursing Consultations

Journal of Clinical Nursing, Volume 35, Issue 6, Page 2744-2754, June 2026.
ABSTRACT Objective To describe the clinical profile, comorbidity burden, follow‐up and healthcare utilisation in patients labelled as having Chronic Obstructive Pulmonary Disease (COPD) in Primary Care (PC) nursing consultations. Design Real‐world data COPD, retrospective, observational study using routinely collected data in electronic health records (
Marc Vila, Meritxell Mondejar, Sergio Cazorla‐Calderón, Àngels Ballarin, Sandra Casas‐Recasens, Rosa Faner, Alvar Agustí   +6 more
wiley   +1 more source