Results 221 to 230 of about 40,592 (266)

Developing the Ideal Inhaled Corticosteroid

Chest, 2006
Inhaled corticosteroids (ICS) are considered the most effective asthma therapy, but concerns remain about side effects. The ideal ICS would have a larger therapeutic ratio than currently available agents, allowing doses to be increased but without greatly increasing the frequency or severity of adverse events.
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Inhaled Corticosteroid Treatment for Asthma

Allergy and Asthma Proceedings, 1995
Increased numbers of goblet cells associated with decrease in the ciliated epithelium occur at an early stage in the patient with asthma. Recent bronchial biopsy studies have demonstrated that these changes may occur even in the mildest asthmatic patient.
L A, Laitinen, A, Laitinen
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Inhaled corticosteroids—effect on bone?

Respiratory Medicine, 1993
Asthmatic patients receiving long-term therapy with oral prednisolone have been found to have an increased incidence of vertebral fractures. Measurements of bone density have shown that diminished bone density is associated with administration of oral corticosteroids rather than with the disease.
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Systemic effects of inhaled corticosteroids

Current Opinion in Pulmonary Medicine, 2012
Although inhaled corticosteroids (ICSs) are the mainstay of therapy in asthma, their use raises certain safety concerns. We review the articles appearing in the last year which have addressed the safety of ICSs when used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).Recent studies suggest that patients with asthma as ...
Pierre, Ernst, Samy, Suissa
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Inhaled Corticosteroids in Children

Drug Safety, 1993
Inhaled corticosteroids are effective for the treatment of asthma. Because of the appreciation of the importance of airway inflammation in the pathogenesis of the disease, these drugs are being used more frequently not only in severe but also in moderate asthma.
BONER, Attilio, PIACENTINI, Giorgio
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[Inhaled corticosteroids for COPD].

Nederlands tijdschrift voor geneeskunde, 2003
Over 60% of patients with COPD are treated with inhaled corticosteroids (ICS), even though their use is still subject to debate. The inflammatory process in the lungs of patients with COPD is dominated by macrophages, CD8+ T-lymphocytes, neutrophilic granulocytes and mast cells, as well as an increased production and/or concentration of IL-8, TNF-alpha
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Advances in inhaled corticosteroid pharmacology

Allergy and Asthma Proceedings, 2007
Inhaled corticosteroids have been the backbone of asthma therapy for the past 20 plus years. Although they have, for the most part, been effective in controlling asthma symptoms and preventing exacerbations, not all patients are universally responsive to their beneficial effects.
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Inhaled Corticosteroids in Airways Disease

2009
I. Introduction Asthma therapy was revolutionized in the early 1970s by the introduction of inhaled corticosteroid (ICS) therapy. ICS therapy has subsequently proved to be the most effective anti-inflammatory treatments for asthma control. Because of the success of ICS for asthma and the realization that chronic obstructive pulmonary disease (COPD) is ...
Adcock I. M., Chung K. F., CARAMORI, Gaetano   +2 more
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Pharmacokinetics and pharmacodynamics of inhaled corticosteroids

Journal of Allergy and Clinical Immunology, 1998
There are significant differences in the pharmacokinetic properties of inhaled corticosteroids currently used in medical practice. All are rapidly cleared from the body but they show varying levels of oral bioavailability and more importantly variation in the rate of absorption after inhalation. Oral bioavailability is lowest for fluticasone propionate,
H, Derendorf, G, Hochhaus, B, Meibohm, H, Möllmann, J, Barth   +4 more
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Effect of Inhaled Corticosteroids on Growth

Pediatrics, 2001
To the Editor. I read with interest the meta-analysis of Sharek and Bergman1 regarding the effect of inhaled corticosteroids (ICS) on growth, and felt it was important to address 2 issues in response. First, the authors' analysis of the growth effect seen during treatment with fluticasone propionate (FP) 200 μg/day indicated a small but statistically
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