Results 61 to 70 of about 3,797,701 (299)
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Chemical Engineering Transactions, 2020 Safety is an aspect of primary relevance in early-process design and can hardly be neglected: the consequences of accidents in chemical plants have always high impact on economics and reputation.
Mariasole Cipolletta +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Emerging small modular nuclear power reactors: A critical review
Physics Open, 2020 This paper reviews the smallness, modularity and reactor-design aspects of emerging small modular reactors (SMRs). It is shown that small (whether in physical size or power level) reactors are not new, but offer economic and flexibility advantages that ...
Esam M.A. Hussein
doaj +1 more source
Inherent Safety in Offshore Drilling Operations
International Journal of Recent Technology and Engineering (IJRTE), 2019 Inherent safety (IS) is a proactive approach for safety management during process plant design and operation. It has been proven that, considering the lifetime costs of a process and its operation, an inherently safer approach is an environmentally friendly and cost-optimal option. IS can be incorporated at any stage of design and operation.
Siti Rafidah Ab Rashid* +1 more
openaire +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Experimental Parameter Study and Inherent Scattering of Safety Characteristics of Dusts
Chemical Engineering Transactions, 2023 Safety characteristics are widely used in industrial processes to avoid explosive atmospheres (primary explosion protection) or to mitigate the consequences of an explosion (constructive explosion protection).
Stefan H. Spitzer +2 more
doaj
Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source
Nuclear Engineering and Technology, 2016 The Prototype Gen IV sodium cooled fast reactor (PGSFR) has been developed for the last 4 years, fulfilling the technology demonstration of the burning capability of transuranic elements included in light water reactor spent nuclear fuel.
Jaewoon Yoo +7 more
doaj +1 more source