Results 11 to 20 of about 220,984 (248)
A small-molecule compound D6 overcomes EGFR-T790M-mediated resistance in non-small cell lung cancer
Communications Biology, 2021 Tang et al. propose the use of a small molecule compound D6 to treat EGFRTKI resistant tumors. The authors demonstrate potent and selective inhibition of NSCLC with T790M-mediated EGFR-TKI resistance through inhibiting HSP90-mediated protein–protein ...
Xiaolong Tang +11 more
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Foods, 2023 Post-mortem aging could enhance the unique flavors of beef via several biochemical pathways. The microbiota is one of the important factors in the flavor development of aging beef, but their potential relationship has rarely been studied.
Hengpeng Wang +6 more
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Prion, 2008 Early cell biologists perceived centrosomes to be permanent cellular structures. Centrosomes were observed to reproduce once each cycle and to orchestrate assembly a transient mitotic apparatus that segregated chromosomes and a centrosome to each daughter at the completion of cell division.
openaire +2 more sources
Frontiers in Psychiatry, 2018 MicroRNA-137 (miRNA-137; miR-137) is one of the important post-transcriptional regulators of the nervous system development, and its MIR137 gene rs1625579 polymorphism was reported to be a potential regulator for schizophrenia susceptibility.
Hanna Kandratsenka +7 more
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Frontiers in Chemistry, 2021 Ganoderma fungi as popular raw materials of numerous functional foods have been extensively investigated. In this study, five pairs of meroterpenoid enantiomers beyond well-known triterpenoids and polysaccharides, dayaolingzhiols I−M (1–5), were ...
Jiao-Jiao Zhang +7 more
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GIS-based precise predictive model of mountain beacon sites in Wenzhou, China
Scientific Reports, 2022 In ancient China, where was frequently troubled by invaders, the government set up many beacon towers for alerting and transmitting military information along the border and the coast.
Lifeng Tan +3 more
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Scientific DataDried roots of Zanthoxylum nitidum (2n=2x=70, family Rutaceae) was referred as “Liang-Mian-Zhen” in Chinese, acting as a valuable species due to its notable pharmacological activities.
Yanxia Zhu +5 more
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LandTraditional villages are important carriers of cultural heritage, and the quantitative study of their spatial characteristics is an important approach to their preservation.
Zhe Li, Tianlian Wang, Su Sun
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Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Highly contiguous genome of the medicinal plant Sarcandra glabra (Thunb.) Nakai
Scientific DataSarcandra glabra (Thunb.) Nakai, a member of the family Chloranthaceae, has a rich history of use in traditional Chinese medicine. To date, >400 compounds have been isolated and characterized from this plant. Studying the genome of S.
Ying Hu +10 more
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