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Critical Reviews in Clinical Laboratory Sciences, 2006
Inherited thrombophilia can be defined as a genetically determined predisposition to the development of thromboembolic complications. Since the discovery of activated protein C resistance in 1993, several additional disorders have been described and, at present, it is possible to identify an inherited predisposition in about 60 to 70% of patients with ...
Giuseppe Lippi, Massimo Franchini
exaly +6 more sources
Inherited thrombophilia can be defined as a genetically determined predisposition to the development of thromboembolic complications. Since the discovery of activated protein C resistance in 1993, several additional disorders have been described and, at present, it is possible to identify an inherited predisposition in about 60 to 70% of patients with ...
Giuseppe Lippi, Massimo Franchini
exaly +6 more sources
Journal of Pharmacy Practice, 2014
Thrombophilia alters normal hemostasis, shifting the balance in favor of thrombus formation. Inherited conditions include factor V Leiden (FVL), prothrombin G20210A mutation, deficiencies in natural anticoagulants (antithrombin [AT], protein C, and protein S), hyperhomocysteinemia, and elevations in clotting factors (factors VIII and XI).
Lori B Hornsby, Sarah Treadway
exaly +3 more sources
Thrombophilia alters normal hemostasis, shifting the balance in favor of thrombus formation. Inherited conditions include factor V Leiden (FVL), prothrombin G20210A mutation, deficiencies in natural anticoagulants (antithrombin [AT], protein C, and protein S), hyperhomocysteinemia, and elevations in clotting factors (factors VIII and XI).
Lori B Hornsby, Sarah Treadway
exaly +3 more sources
Inherited Thrombophilia and Venous Thromboembolism
Seminars in Thrombosis and Hemostasis, 2006The term thrombophilia includes any inherited and acquired disorders associated with an increased tendency to venous thromboembolism (VTE). Inherited thrombophilia is one of the main determinants of VTE, and the presence of inherited thrombophilic defects exposed carriers to increased risks for VTE compared with noncarriers.
Paolo Prandoni +2 more
exaly +4 more sources
Obstetrics and Gynecology Clinics of North America, 2006
Many inherited thrombophilias have been detected and the pathophysiologic insight has increased tremendously during the last decades. Despite, however, the overwhelming observational evidence on the association between inherited thrombophilia and several women's health issues, including VTE, thus far the implications for clinical practice are uncertain.
Coppens, Michiel +2 more
openaire +3 more sources
Many inherited thrombophilias have been detected and the pathophysiologic insight has increased tremendously during the last decades. Despite, however, the overwhelming observational evidence on the association between inherited thrombophilia and several women's health issues, including VTE, thus far the implications for clinical practice are uncertain.
Coppens, Michiel +2 more
openaire +3 more sources
Inherited and Acquired Thrombophilias
Reproductive Sciences, 2014Thrombophilias represent an evolving story that continues to stir controversy for care providers and obstetrical patients. The predominant thrombophilic mutations include the factor V Leiden mutation, prothrombin gene mutation G20210A, methylene tetrahydrafolate reductase C667T, and deficiencies of the natural anticoagulants proteins C and S, and ...
Rambaldi MP +3 more
openaire +4 more sources
Inherited Thrombophilia in Children
Current Problems in Pediatric and Adolescent Health Care, 2013Thrombosis in children has multiple etiologies, including inherited disorders such as factor V Leiden mutation, prothrombin 20210A mutation, and deficiencies in protein C, S, or antithrombin. Epidemiology of the disorders varies, as does the risk of thrombosis. Venous thromboembolism is the typical presentation.
Michael, Silvey, Shannon L, Carpenter
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Inherited thrombophilia and stillbirth
Seminars in Perinatology, 2002Thrombophilias are inherited or acquired conditions that predispose individuals to thromboembolism. New inherited thrombophilias are recognized each year. Some, but not all, studies have found an association between inherited thrombophilias and adverse pregnancy outcomes, including fetal loss.
George R, Saade, Claire, McLintock
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