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Inherited thrombophilia and pregnancy
Current Opinion in Obstetrics and Gynaecology, 1998Inherited thrombophilia is associated with an increased risk of thrombosis. Classically it consists of protein C and protein S deficiency, activated protein C resistance and antithrombin III deficiency. In pregnancy, in addition to thrombosis, inherited thrombophilia is associated with poor obstetric outcome, including recurrent miscarriage, late fetal
J, Girling, M, de Swiet
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Inherited Thrombophilia and the Eye
Seminars in Ophthalmology, 2008Inherited thrombophilic disorders are a well-recognized risk factor for systemic thromboembolism. These disorders include deficiencies of anticoagulant proteins such as protein C, protein S, and antithrombin III, abnormalities of factor V and prothrombin resulting from genetic mutations, and hyperhomocysteinemia.
Cheryl, Czerlanis +2 more
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Management of Inherited Thrombophilia in Pregnancy [PDF]
Women's Health, 2016 Adverse pregnancy outcomes, such as pregnancy loss and pre-eclampsia, are associated with thrombotic mechanisms and thrombophilia. Antithrombotic interventions, particularly low-molecular-weight heparin, have been investigated in women identified by previous pregnancy outcome; however, the results have been inconsistent.
Laura Ormesher, Louise Simcox, Ian Greer
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Inherited Thrombophilia and Pregnancy Loss
Thrombosis and Haemostasis, 1999IntroductionA successful pregnancy is dependent on the development of adequate placental circulation. Abnormalities of placental vasculature may result in a number of gestational pathologies, including first and second trimester miscarriages, intrauterine growth retardation (IUGR), intrauterine fetal death (IUFD), placental abruption, and preeclampsia ...
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Sex, thrombosis and inherited thrombophilia
Blood Reviews, 2014The incidence of venous thromboembolism (VTE) is two-fold higher in women than in men during reproductive age, which is likely explained by the use of hormonal contraceptives and by pregnancy in this phase of life. After adjustment for these factors, men have a two-fold higher risk of developing a first VTE compared with women, which is in line with ...
Suzanne M, Bleker +2 more
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Inherited thrombophilias and anticoagulation in pregnancy
Best Practice & Research Clinical Obstetrics & Gynaecology, 2003Thromboprophylaxis, primary or secondary, should be considered in selected pregnant women with inherited thrombophilias; such women may be divided into high-, medium- and low-risk categories on the basis of the specific thrombophilic defect and any personal or family history of venous thromboembolism (VTE).
Louise, Bowles, Hannah, Cohen
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Inherited Thrombophilia Genes in Minorities
Genetic Testing, 1999Mutations in several genes have recently been identified which predispose to thrombosis, specifically Factor V G1691A (Factor V Leiden), Prothrombin G20210A, and Methylene tetrahydrofolate reductase (MTHFR) C677T. The prevalence of these genes in European populations has been studied, but there is little data on their prevalence in minorities.
R, Mack +3 more
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Hunting for the mutation in inherited thrombophilia
Blood Coagulation & Fibrinolysis, 2004Mutation detection in inherited thrombophilia remains largely confined to the research laboratory. However, there are specific situations when investigating the genetic defect causing thrombophilia can provide additional useful clinical information. This review discusses the value of genetic analysis in the common inherited thrombophilias.
Keith, Gomez, Michael A, Laffan
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Recenti progressi in medicina, 2005
Inherited thrombophilia can be defined as a genetically determined predisposition to develop thromboembolic complications. Inherited prothrombotic risk factors include antithrombin deficiency, protein C and protein S deficiencies, activated protein C resistance due to Leiden factor V mutation, inherited hyperhomocysteinemia, prothrombin G20210A variant,
Massimo, Franchini, Dino, Veneri
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Inherited thrombophilia can be defined as a genetically determined predisposition to develop thromboembolic complications. Inherited prothrombotic risk factors include antithrombin deficiency, protein C and protein S deficiencies, activated protein C resistance due to Leiden factor V mutation, inherited hyperhomocysteinemia, prothrombin G20210A variant,
Massimo, Franchini, Dino, Veneri
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Perinatal Aspects of Inherited Thrombophilia
Seminars in Thrombosis and Hemostasis, 1999The identified main causes of inherited thrombophilia are deficiencies of antithrombin, protein C and protein S, activated protein C (APC) resistance and the factor V Leiden mutation, mutant factor II, and inherited hyperhomocysteinemia. In women from symptomatic families these defects may be associated with an increased risk of venous thrombosis in ...
J, Bonnar, R, Green, L, Norris
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