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The molecular mechanisms of inherited thrombophilia
Zeitschrift für Kardiologie, 2000Venous Thromboembolism develops as the result of multiple interactions between non-genetic and genetic risk factors. The most important non-genetic risk factors are age, tissue damage, oral contraception, pregnancy, obesity and lack of physical activity. Inborn factors predisposing to thrombosis are present in the majority of patients.
März, Winfried +2 more
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Management of inherited thrombophilia in pregnancy
Current Opinion in Endocrinology, Diabetes & Obesity, 2009This review summarizes the currently available data concerning risk and management of venous thromboembolism in pregnant women with inherited thrombophilia.Pregnancy is a hypercoagulable state, and inherited thrombophilia increases this risk further.
Annemarie E, Fogerty, Jean M, Connors
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The Molecular Basis of Inherited Thrombophilia
Vox Sanguinis, 2000SummaryEven though it has been known for centuries that inherited defects of blood coagulation cause lifelong bleeding disorders. the existence of the counterpart, inherited thrombotic disorders, has been appreciated for only a few decades. Inherited thrombophilia can be defined as a genetically determined tendency to venous thromboembolism which ...
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Genetic counseling for inherited thrombophilias
Journal of Thrombosis and Thrombolysis, 2007Genetic testing for inherited thrombophilia, including mutation analysis for factor V Leiden and prothrombin G20210A, is commonly performed. Yet, tests for inherited thrombophilia are frequently ordered inappropriately, and without proper counseling about the risks, benefits and limitations of testing.
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Inherited thrombophilia and venous thromboembolism
Best Practice & Research Clinical Obstetrics & Gynaecology, 2003Pulmonary thromboembolism (PTE) is the major cause of maternal death in the UK. Underlying PTE is the problem of deep venous thrombosis (DVT). Inherited thrombophilia will be found in about 50% of women with a personal history of venous thromboembolism (VTE), and screening for thrombophilia should be considered in women with a personal or family ...
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Thrombophilia can be defined as laboratory abnormalities, usually in the coagulation system, that result in a hypercoagulable state and thus predispose to thrombosis. These abnormalities may be acquired or inherited. The most clearly established form of acquired thrombophilia is the antiphospholipid anti- body syndrome.
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Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia, 2009
The paradigm of inherited thrombophilia as a cause of unprovoked venous thrombosis among young people and associated with a high clinical penetrance among members of the same kindred is challenged by many diagnosed cases not fitting this paradigm, although inherited thrombophilia is still the most likely diagnosis in most cases.
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The paradigm of inherited thrombophilia as a cause of unprovoked venous thrombosis among young people and associated with a high clinical penetrance among members of the same kindred is challenged by many diagnosed cases not fitting this paradigm, although inherited thrombophilia is still the most likely diagnosis in most cases.
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Inherited thrombophilia and fetal loss
Current Opinion in Hematology, 2000Acquired thrombophilia is a well-established cause of pregnancy loss. Increasing numbers of recent observations suggest that inherited thrombophilia is not only associated with gestational thromboembolism but is also a major cause of fetal loss. This review focuses on association of fetal loss with inherited thrombophilias, including dysfibrinogenemia ...
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