A call to action: MTHFR polymorphisms should not be a part of inherited thrombophilia testing. [PDF]
Res Pract Thromb Haemost, 2022 Testing for polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene is still a standard part of thrombophilia testing in many laboratories. However, it is clear that these polymorphisms are not risk factors for arterial or venous thrombosis
Deloughery TG +4 more
europepmc +2 more sources
Inherited thrombophilia is significantly associated with severe preeclampsia. [PDF]
Exp Ther Med, 2021 Methods to prevent the development of pathologies due to placental dysfunctions, such as gestational hypertension and preeclampsia, are the main approaches for obtaining the best maternal and fetal antepartum and postpartum prognosis.
Bohiltea RE +9 more
europepmc +2 more sources
Inherited thrombophilia in pediatric venous thromboembolic disease: Why and who to test [PDF]
Frontiers in Pediatrics, 2017 Venous thromboembolic disease in childhood is a multifactorial disease. Risk factors include acquired clinical risk factors such as a central venous catheter and underlying disease and inherited thrombophilia.
Nowak-Göttl, U. (Ulrike) +1 more
core +9 more sources
Inherited thrombophilia in a patient with colorectal carcinoma [PDF]
Gastroenterology Review, 2019 Matej Hrnčár +4 more
doaj +4 more sources
Morphometric and Nanomechanical Features of Platelets from Women with Early Pregnancy Loss Provide New Evidence of the Impact of Inherited Thrombophilia. [PDF]
Int J Mol Sci, 2021 Pregnancy is associated with hypercoagulation states and increased thrombotic risk, especially in women with thrombophilia. We combine atomic force microscopy (AFM) and flow cytometry to examine the morphology and nanomechanics of platelets derived from ...
Andreeva T +10 more
europepmc +2 more sources
Haematologica, 2009 It is uncertain whether the JAK2 V617F mutation increases the thrombotic risk in patients with essential thrombocythemia, and it is unknown whether inherited thrombophilia is an additive risk factor in mutated subjects.
Valerio De Stefano +8 more
doaj +3 more sources
Inherited thrombophilia: Diagnostic approach
Iraqi Journal of Hematology, 2017 Hemostatic abnormalities include both bleeding and thrombosis disorders. Adherence to most common guidelines for the diagnosis of thrombophilia is recommended especially in some developing countries.
Rahem Mahdy Rahem +1 more
doaj +2 more sources
Primary prophylaxis of venous thromboembolic disease with direct oral anticoagulants in patients with severe inherited thrombophilia [PDF]
Research and Practice in Thrombosis and Haemostasis, 2021 Direct oral anticoagulants (DOACs) are widely used in several indications, but data on their efficacy and safety in individuals affected by severe inherited thrombophilia, yet without any personal history of thrombosis, is lacking.
Evelien Krumb, Cedric Hermans
doaj +2 more sources
Maternal inherited thrombophilia and pregnancy outcomes. [PDF]
Exp Ther Med, 2020 Thrombophilia is a group of genetical disorders that cause blood to clot abnormally. Thrombophilia is linked to recurrent pregnancy loss, foetal growth restriction, late miscarriages, stillbirth and preeclampsia.
Voicu DI +6 more
europepmc +2 more sources
Impact of Inherited Thrombophilia on Pregnancy Complications and the Role of Low-Molecular-Weight Heparin Therapy: A Case–Control Study [PDF]
MedicinaBackground and Objectives: Inherited thrombophilia (IT) increases the risk of adverse pregnancy outcomes, but the benefit of low-molecular-weight heparin (LMWH) prophylaxis remains debated.
Dragana Maglic +5 more
doaj +2 more sources