Activins and Inhibins in Cardiovascular Pathophysiology [PDF]
BiomoleculesActivins and inhibins, members of the transforming growth factor β (TGFβ) superfamily, were initially recognized for their opposing effects on the secretion of follicle-stimulating hormone.
Wenyi Tang +6 more
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Key role for inhibins in effective T cell activation, migration and Th17 differentiation [PDF]
FEBS Open BioOur group has previously reported that inhibin and its molecular pair, TGF‐β type III receptor (TβRIII), regulate T cell development within the thymus. In addition, inhibins play a key role in immune tolerance through the modulation of dendritic cell (DC)
Sandra Ortega‐Francisco +5 more
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The Role of TGF-β Signaling Pathway in Determining Small Ruminant Litter Size [PDF]
BiologyThe transforming growth factor-beta (TGF-β) superfamily plays a crucial role in regulating female reproductive traits, particularly litter size, in small ruminants, such as sheep and goats.
Ying Han +4 more
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Immunolocalization of activin and inhibin at different stages of follicular development in the lizard Sceloporus torquatus [PDF]
Heliyon, 2023 The activins and inhibins are glycoproteins with a role in the follicular development of vertebrates, that are found in follicular fluid and somatic follicular cells, with a different pattern among taxa.
N.B. Cruz-Cano +5 more
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Maternal TGF-β ligand Panda breaks the radial symmetry of the sea urchin embryo by antagonizing the Nodal type II receptor ACVRII. [PDF]
PLoS BiologyIn the highly regulative embryo of the sea urchin Paracentrotus lividus, establishment of the dorsal-ventral (D/V) axis critically depends on the zygotic expression of the TGF-β nodal in the ventral ectoderm.
Praveen Kumar Viswanathan +4 more
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Dual signaling pathways of TGF-β superfamily cytokines in hepatocytes: balancing liver homeostasis and disease progression [PDF]
Frontiers in PharmacologyThe transforming growth factor-β (TGF-β) superfamily (TGF-β-SF) comprises over 30 cytokines, including TGF-β, activins/inhibins, bone morphogenetic proteins (BMPs), and growth differentiation factors (GDFs).
Roohi Chaudhary +4 more
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PLoS ONE, 2021 Inhibins and activins are dimeric ligands belonging to the TGFβ superfamily with emergent roles in cancer. Inhibins contain an α-subunit (INHA) and a β-subunit (either INHBA or INHBB), while activins are mainly homodimers of either βA (INHBA) or βB ...
Eduardo Listik +5 more
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Betaglycan (TβRIII) is expressed in the thymus and regulates T cell development by protecting thymocytes from apoptosis. [PDF]
PLoS ONE, 2012 TGF-β type III receptor (TβRIII) is a coreceptor for TGFβ family members required for high-affinity binding of these ligands to their receptors, potentiating their cellular functions.
German R Aleman-Muench +6 more
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A Key Role for Inhibins in Dendritic Cell Maturation and Function. [PDF]
PLoS ONE, 2016 Inhibins are members of the TGFβ superfamily, which regulate many cellular processes including differentiation, proliferation, survival and apoptosis. Although initially described as hormones regulating the hypothalamus-pituitary-gonadal axis, based on ...
Roxana Olguín-Alor +5 more
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Frontiers in Endocrinology, 2021 Obesity is a global health problem and a major risk factor for several metabolic conditions including dyslipidemia, diabetes, insulin resistance and cardiovascular diseases.
Shehla Pervin +6 more
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