Results 91 to 100 of about 3,537,635 (306)
Inhibition of bovine kidney low molecular mass phosphotyrosine protein phosphatase by uric acid
, 2015 Uric acid inhibited 50% of the activity of bovine kidney low molecular mass phosphotyrosine protein phosphatase at concentrations of 1.0, 0.4, 1.3, and 0.2 mM, respectively for p -nitrophenyl phosphate (p -NPP), flavine mononucleotide, beta-naphthyl ...
Volpe, PLO +6 more
core +2 more sources
Navigating Drug–Drug Interactions in Clinical Drug Development: A Tutorial
Clinical and Translational ScienceThis tutorial provides essential guidelines and insights, in addition to regulatory guidance, for the evaluation of drug–drug interactions (DDIs), with a focus on the tools and timing of assessment critical for effective management of inclusion/exclusion
Jesmin Lohy Das +2 more
doaj +1 more source
Age Effect on Automatic Inhibitory Function of the Somatosensory and Motor Cortex: An MEG Study
Frontiers in Aging Neuroscience, 2018 Age-related deficiency in the top-down modulation of cognitive inhibition has been extensively documented, whereas the effects of age on a bottom-up or automatic operation of inhibitory function were less investigated.
Chia-Hsiung Cheng +7 more
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Inhibition of activity of GABA transporter GAT1 by δ-opioid receptor [PDF]
, 2012 Analgesia is a well-documented effect of acupuncture. A critical role in pain sensation plays the nervous system, including the GABAergic system and opioid receptor (OR) activation.
Fucke, Thomas +7 more
core +1 more source
AgronomyMoringa (Moringa oleifera Lam.) is widely recognised as a multipurpose crop suitable for human and animal consumption, medicinal, and industrial purposes, making it attractive for introduction into new ranges.
Blair Moses Kamanga +3 more
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
The Whole Day Movement Matters to Executive Function Among College Students
Behavioral Sciences“The whole day movement matters to health.” has become an important topic while the associations between executive function and different movement behaviors (i.e., physical activity (PA), sedentary behavior (SB) and sleep) are traditionally examined in ...
Xiaoxia Zhang +4 more
doaj +1 more source
Feedback Enhances Preschoolers’ Performance in an Inhibitory Control Task
Frontiers in Psychology, 2019 Accomplishing inhibition tasks requires not only inhibitory skills but also goal maintenance. The present study aimed to disentangle goal maintenance from inhibition. Therefore, we experimentally manipulated goal-maintenance demands by means of feedback.
Niamh Oeri +3 more
doaj +1 more source