Results 81 to 90 of about 6,398,774 (357)

Angiotensin–Neprilysin Inhibition in Acute Decompensated Heart Failure

New England Journal of Medicine, 2019
BACKGROUND Acute decompensated heart failure accounts for more than 1 million hospitalizations in the United States annually. Whether the initiation of sacubitril–valsartan therapy is safe and effective among patients who are hospitalized for acute ...
E. Velazquez, D. Morrow, A. DeVore, Carol I. Duffy, A. Ambrosy, K. Mccague, Ricardo A. Rocha, E. Braunwald   +7 more
semanticscholar   +1 more source

Intravital Multiphoton Microscopy with Fluorescent Bile Salts in Rats as an In Vivo Biomarker for Hepatobiliary Transport Inhibition [PDF]

, 2018
The bile salt export pump (BSEP) is expressed at the canalicular domain of hepatocytes, where it mediates the elimination of monovalent bile salts into the bile.
Chen, Yuan, Dunn, Kenneth W., Dunn, Robert T., Morgan, Ryan E., Ryan, Jennifer, Volak, Laurie P.   +5 more
core   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Purification and Component Analysis of Total Flavonoids from Sea Buckthorn Peel Residue and Its Anti-Pancreatic Lipase

Shipin gongye ke-ji
In order to clarify the inhibition of total flavonoids purified extract (TFSE) of sea buckthorn peel residue on pancreatic lipase, this research optimized the purification condition of total flavonoids crude extract (TFCE) of sea buckthorn peel residue ...
Jiali SUN, Junfeng JIANG, Xiaojuan MOU, Zehui ZONG, Siyu YAN, JIALALIDING·Remuzha, Xiaowei BAO   +6 more
doaj   +1 more source

Morphological and Transcriptomic Analysis of the Inhibitory Effects of Lactobacillus plantarum on Aspergillus flavus Growth and Aflatoxin Production

Toxins, 2019
Lactobacillus plantarum, as a natural bio-preservative, has attracted a great deal of attention in recent years. In this study, 22 L. plantarum strains were tested against the aflatoxin-producing fungus, Aspergillus flavus; strain IAMU80070 showed the ...
Yueju Zhao, Chenxi Zhang, Yawa Minnie Elodie Folly, Jinghua Chang, Yan Wang, Lu Zhou, Heping Zhang, Yang Liu   +7 more
doaj   +1 more source

CDK4/6 inhibition triggers anti-tumor immunity

Nature, 2017
Cyclin-dependent kinases 4 and 6 (CDK4/6) are fundamental drivers of the cell cycle and are required for the initiation and progression of various malignancies.
S. Goel, Molly J Decristo, April C. Watt, Haley BrinJones, Jaclyn Sceneay, Ben B. Li, N. Khan, Jessalyn M. Ubellacker, Shaozhen Xie, O. Metzger-Filho, J. Hoog, M. Ellis, Cynthia X. Ma, S. Ramm, I. Krop, E. Winer, T. Roberts, Hye-Jung Kim, S. McAllister, Jean J. Zhao   +19 more
semanticscholar   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Measuring semantic memory using associative and dissociative retrieval tasks

Royal Society Open Science
Recent theoretical advances highlighted the need for novel means of assessing semantic cognition. Here, we introduce the associative-dissociative retrieval task (ADT), positing a novel way to test inhibitory control over semantic memory retrieval by ...
Martin Marko, Drahomír Michalko, Adam Kubinec, Igor Riečanský   +3 more
doaj   +1 more source

Dietary Protein Intake and Peritoneal Protein Losses in Peritoneal Dialysis Patients

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) patients lose protein in their waste dialysate, potentially increasing their risk for malnutrition. We wished to determine whether there was any association between losses and dietary protein intake (DPI). Methods DPI was assessed from 24‐h dietary recall using Nutrics software.
Haalah Shaaker, Andrew Davenport
wiley   +1 more source

Molecular modeling, synthesis and biological evaluation of caffeic acid based Dihydrofolate reductase inhibitors

BMC Chemistry
Dihydrofolate reductase (DHFR) is an enzyme that plays a crucial role in folate metabolism, which is essential for cell growth and division. DHFR has been identified as a molecular target for numerous diseases due to its significance in various ...
Renu Sehrawat, Ritu Pasrija, Priyanka Rathee, Deepika Kumari, Anurag Khatkar   +4 more
doaj   +1 more source