Results 81 to 90 of about 4,234,264 (316)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Insight into the mechanism of ferroptosis inhibition by ferrostatin-1

Redox Biology, 2019
Ferroptosis is a form of cell death primed by iron and lipid hydroperoxides and prevented by GPx4. Ferrostatin-1 (fer-1) inhibits ferroptosis much more efficiently than phenolic antioxidants.
G. Miotto, Monica Rossetto, M. D. Di Paolo, L. Orian, R. Venerando, A. Roveri, Ana-Marija Vučković, Valentina Bosello Travain, Mattia Zaccarin, L. Zennaro, M. Maiorino, S. Toppo, F. Ursini, G. Cozza   +13 more
semanticscholar   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Lignocellulosic composites from brazilian giant bamboo (Guadua magna). Part 2: Properties of cement and gypsum bonded particleboards

Maderas: Ciencia y Tecnología, 2014
In the first part of this study, the feasibility of manufacturing resin-bonded particleboard from the recently identified Brazilian giant bamboo (Guadua magna) was evaluated.
Priscila C. de Araújo, Larissa M. Arruda, Cláudio H. S. Del Menezzi, Divino E. Teixeira, Mário R. de Souza   +4 more
doaj  

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

Cell Metabolism, 2016
SUMMARY Remodeling of the tricarboxylic acid (TCA) cycle is a metabolic adaptation accompanying inflammatory macrophage activation. During this process, endogenous metabolites can adopt regulatory roles that govern specific aspects of inflammatory ...
Vicky Lampropoulou, A. Sergushichev, M. Bambouskova, S. Nair, E. Vincent, Ekaterina Loginicheva, L. Cervantes-Barragan, Xiucui Ma, S. C. Huang, Takla Griss, C. Weinheimer, S. Khader, G. Randolph, E. Pearce, Russell G. Jones, A. Diwan, M. Diamond, M. Artyomov   +17 more
semanticscholar   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Effect of diethylstilbestrol on skin sterols of the male rat

Journal of Lipid Research, 1968
Diethylstilbestrol (DES) was injected in doses ranging from 600 μg to 0.4 μg/kg body weight into mature male rats over a 3 wk period. Profound effects on skin morphology and on sterol content of skin were noted.
L. Horlick
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Navigating Drug–Drug Interactions in Clinical Drug Development: A Tutorial

Clinical and Translational Science
This tutorial provides essential guidelines and insights, in addition to regulatory guidance, for the evaluation of drug–drug interactions (DDIs), with a focus on the tools and timing of assessment critical for effective management of inclusion/exclusion
Jesmin Lohy Das, Antoinette (Toni) Ajavon‐Hartmann, Virginia (Ginny) D. Schmith   +2 more
doaj   +1 more source

Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers

Nature Medicine, 2019
Pancreatic ductal adenocarcinoma (PDA) was responsible for ~ 44,000 deaths in the United States in 2018 and is the epitome of a recalcitrant cancer driven by a pharmacologically intractable oncoprotein, KRAS1–4.
C. Kinsey, S. Camolotto, A. Boespflug, Katrin P. Guillen, M. Foth, A. Truong, Sophia Schuman, Jill E. Shea, M. Seipp, Jeffrey Yap, Lance D. Burrell, David H. Lum, Jonathan R. Whisenant, G. Gilcrease, Courtney C. Cavalieri, Kaitrin M. Rehbein, Stephanie L. Cutler, Kajsa E. Affolter, A. Welm, B. Welm, Courtney L. Scaife, Eric L. Snyder, M. McMahon   +22 more
semanticscholar   +1 more source