Results 81 to 90 of about 3,445,280 (251)

Evidence that inhibition of phorbol ester-induced superoxide anion formation by cyclosporin A in phagocytes is not mediated by direct inhibition of protein kinase C [PDF]

, 1994
Cyclosporin A (CsA) has been reported to inhibit phorbol myristate acetate (PMA)-induced superoxide anion (O2-) formation in human neutrophils and murine macrophages.
Grünbaum, L., Hummel, R., Schächtele, C., Wenzel-Seifert, K., Seifert, Roland   +4 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Predicting sexual problems in women: The relevance of sexual excitation and sexual inhibition [PDF]

, 2007
This is the post-print version of the article. The official published version can be obtained from the link below.Data from a non-clinical sample of 540 heterosexual women were used to examine the relationships between scores on the Sexual Excitation ...
Milhausen, RR, Sanders, Stephanie A., Milhausen, Robin R., Sanders, SA, Graham, CA, Graham, Cynthia A.   +5 more
core   +1 more source

The Open Enzyme Inhibition Journal

The Open Enzyme Inhibition Journal (ISSN: 1874-9402) is an Open Access online journal, which publishes research articles, reviews, and letters in all areas of enzyme inhibition ...
BOLOGNESI, ANDREA
core   +1 more source

Navigating Drug–Drug Interactions in Clinical Drug Development: A Tutorial

Clinical and Translational Science
This tutorial provides essential guidelines and insights, in addition to regulatory guidance, for the evaluation of drug–drug interactions (DDIs), with a focus on the tools and timing of assessment critical for effective management of inclusion/exclusion
Jesmin Lohy Das, Antoinette (Toni) Ajavon‐Hartmann, Virginia (Ginny) D. Schmith   +2 more
doaj   +1 more source

Age Effect on Automatic Inhibitory Function of the Somatosensory and Motor Cortex: An MEG Study

Frontiers in Aging Neuroscience, 2018
Age-related deficiency in the top-down modulation of cognitive inhibition has been extensively documented, whereas the effects of age on a bottom-up or automatic operation of inhibitory function were less investigated.
Chia-Hsiung Cheng, Chia-Hsiung Cheng, Chia-Hsiung Cheng, Chia-Hsiung Cheng, Mei-Yin Lin, Mei-Yin Lin, Shiou-Han Yang, Shiou-Han Yang   +7 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The general anaesthetic etomidate inhibits the excitability of mouse thalamocortical relay neurons by modulating multiple modes of GABA_A receptor-mediated inhibition [PDF]

, 2014
Modulation of thalamocortical (TC) relay neuron function has been implicated in the sedative and hypnotic effects of general anaesthetics. Inhibition of TC neurons is mediated predominantly by a combination of phasic and tonic inhibition, together with a
Herd, Murray B., Lambert, Jeremy J., Delia Belelli, Jeremy J. Lambert, Belelli, Delia, Murray B. Herd   +5 more
core   +1 more source

Allelopathic Effects of Moringa oleifera Lam. on Cultivated and Non-Cultivated Plants: Implications for Crop Productivity and Sustainable Agriculture

Agronomy
Moringa (Moringa oleifera Lam.) is widely recognised as a multipurpose crop suitable for human and animal consumption, medicinal, and industrial purposes, making it attractive for introduction into new ranges.
Blair Moses Kamanga, Donita L. Cartmill, Craig McGill, Andrea Clavijo McCormick   +3 more
doaj   +1 more source