Results 71 to 80 of about 4,234,264 (316)

Detection and Inhibition of Clostridium perfringens by Cocktail of Star Anise and Thymus Extracts in Chicken Meat Products

Pathogens
Background: The presence of C. perfringens in chicken meat products leads to significant economic losses for the industry and is associated with human food poisoning.
Gamal M. Hamad, Shenoda Gaber Monir Henry, Gamal E. A. El-Rokh, Nadia H. A. Ramadan, Hany S. Abdel Raoof, Ahmed M. Sulaiman, Ahmed M. El-Mesallamy, Samy E. Elshaer, Sara M. Gaber, Ibrahim M. Rabah, Ahmed R. Mahmoud, Mahmoud S. A. Salama, Taha Mehany, Hesham E. A. Abdelfttah   +13 more
doaj   +1 more source

Studies on the Antibacterial Influence of Two Ionic Liquids and their Corrosion Inhibition Performance

Applied Sciences, 2020
In this paper the anti-bacterial and the anti-corrosion effect of two different ionic liquids, namely 1-(2-hydroxyethyl)-3-methylimidazolinium chloride ([OH-EMIm]Cl) and 1-ethyl-3-methyleimidazolinium chloride ([EMIm]Cl) was demonstrated.
Mohamed F. Shehata, Ashraf M. El-Shamy, Khaled M. Zohdy, El-Sayed M. Sherif, Sherif Zein El Abedin   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

Nature, 2016
Major depressive disorder affects around 16 per cent of the world population at some point in their lives. Despite the availability of numerous monoaminergic-based antidepressants, most patients require several weeks, if not months, to respond to these ...
P. Zanos, R. Moaddel, Patrick J. Morris, Polymnia Georgiou, J. Fischell, G. Elmer, M. Alkondon, P. Yuan, H. Pribut, Nagendra S. Singh, K. S. Dossou, Yuhong Fang, Xi-Ping Huang, Cheryl L. Mayo, I. Wainer, E. Albuquerque, S. Thompson, Craig J. Thomas, C. Zarate, T. Gould   +19 more
semanticscholar   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

MiRNA-Mediated Regulation of S100B: A Review

NeuroSci
S100β is a significant signaling molecule and biomarker that is primarily expressed in the brain. At low physiological concentrations, S100β induces astrocyte maturation, microglial migration, and neural proliferation.
Animesh Dali, Suhana Basnyat, Rachel Delancey, Nipun Chopra   +3 more
doaj   +1 more source

Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders

Molecular Psychiatry, 2019
In 2003 Rubenstein and Merzenich hypothesized that some forms of Autism (ASD) might be caused by a reduction in signal-to-noise in key neural circuits, which could be the result of changes in excitatory-inhibitory (E-I) balance.
V. Sohal, J. Rubenstein
semanticscholar   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Combined BRAF and MEK Inhibition in Melanoma with BRAF V600 Mutations

New England Journal of Medicine, 2012
BACKGROUND Resistance to therapy with BRAF kinase inhibitors is associated with reactivation of the mitogen-activated protein kinase (MAPK) pathway. To address this problem, we conducted a phase 1 and 2 trial of combined treatment with dabrafenib, a ...
K. Flaherty, J. Infante, A. Daud, R. Gonzalez, R. Kefford, J. Sosman, O. Hamid, L. Schuchter, J. Cebon, N. Ibrahim, R. Kudchadkar, H. Burris, G. Falchook, A. Algazi, K. Lewis, G. Long, I. Puzanov, P. Lebowitz, A. Singh, S. Little, P. Sun, A. Allred, D. Ouellet, Kevin B. Kim, K. Patel, J. Weber   +25 more
semanticscholar   +1 more source