Results 61 to 70 of about 6,398,774 (357)

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Shaping Functional Architecture by Oscillatory Alpha Activity: Gating by Inhibition

Frontiers in Human Neuroscience, 2010
In order to understand the working brain as a network, it is essential to identify the mechanisms by which information is gated between regions. We here propose that information is gated by inhibiting task-irrelevant regions, thus routing information to ...
O. Jensen, A. Mazaheri
semanticscholar   +1 more source

Impaired Competence for Pretense in Children with Autism: Exploring Potential Cognitive Predictors. [PDF]

, 2009
Lack of pretense in children with autism has been explained by a number of theoretical explanations, including impaired mentalising, impaired response inhibition, and weak central coherence.
AM Leslie, AM Leslie, AM Leslie, AS Lillard, B Morgan, BG Tabachnick, C Hughes, C Jarrold, C Jarrold, C Jarrold, C Jarrold, DM Ricks, F Happé, F Happé, G Miller, H Wimmer, HA Witkin, J Boucher, J Perner, L Mottron, LM Dunn, M Taylor, MD Rutherford, P Rochat, PL Harris, RD Kavanaugh, S Baron-Cohen, S Baron-Cohen, S Baron-Cohen, S Bigham, S Bigham, Sally Bigham, T Suddendorf, U Frith, U Frith, V Lewis, W Haight   +36 more
core   +1 more source

Dexamethasone for Chemotherapy‐Induced Nausea and Vomiting Prevention in Pediatric Patients: International Consensus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An international Delphi panel of experts developed consensus statements to delineate the circumstances where the risks of dexamethasone as an antiemetic do and do not outweigh its benefits. Procedure Experts in supportive care of pediatric patients were invited to participate.
Negar Shavandi, Paula D. Robinson, Shana Jacobs, L. Lee Dupuis, the International Pediatric Dexamethasone Panel, Sameer Bakhshi, Tiene Bauters, Eva Brack, Simone Cesaro, Claire Fosbrook, Jason Freedman, Tamara MacDonald, Eloise Neumann, Venkatraman Radhakrishnan, Rod Rassekh, Florian Slimano, Johnathan Soggee, Joel Thompson, Marianne van de Wetering, Milena Villarroel, Jasper Wong   +20 more
wiley   +1 more source

Potential anticholinesterase of plants of the Caatinga biome / Potencial anticolinesterásico de plantas do bioma Caatinga

Diversitas Journal, 2018
The caatinga is the only exclusive biome in Brazil, characterized by arboreal or arbusive vegetation, composed of small trees and shrubs of xerophytic peculiarities.
Anderson Soares de Almeida, Aldenir Feitosa dos Santos   +1 more
doaj   +1 more source

KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors.

New England Journal of Medicine, 2020
BACKGROUND No therapies for targeting KRAS mutations in cancer have been approved. The KRAS p.G12C mutation occurs in 13% of non-small-cell lung cancers (NSCLCs) and in 1 to 3% of colorectal cancers and other cancers.
D. Hong, M. Fakih, J. Strickler, J. Desai, G. Durm, G. Shapiro, G. Falchook, T. Price, A. Sacher, C. Denlinger, Y. Bang, G. Dy, J. Krauss, Y. Kuboki, J. Kuo, A. Coveler, Keunchil Park, Tae Won Kim, F. Barlesi, P. Munster, S. Ramalingam, T. Burns, F. Meric-Bernstam, H. Henary, J. Ngang, G. Ngarmchamnanrith, June Kim, B. Houk, J. Canon, J. Lipford, G. Friberg, P. Lito, R. Govindan, Bob T. Li   +33 more
semanticscholar   +1 more source

Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription. [PDF]

, 2020
Deregulated expression of MYC induces a dependence on the NUAK1 kinase, but the molecular mechanisms underlying this dependence have not been fully clarified.
Ade, C.P., Baluapuri, A., Chang, Y.C., Cossa, G., Eilers, M., Girard, C., Kempa, S., Kumar, A., Kuster, B., Lührmann, R., Mastrobuoni, G., Mumberg, D., Prinz, F., Roeschert, I., Schülein-Völk, C., Silveira Vidal, R., Walz, S., Wolf, E., Wortmann, L.   +18 more
core   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Inhibition of Bifidobacterium SP Isolated From Infants Feces Towards Adhesion of Salmonella Typhi on Balb/c Mice Enterocyte [PDF]

, 2010
Diarrhea, up to the recent year remains a cause of high morbidity and mortalityworldwide, especially in developing countries including Indonesia. Research concerning ofmanagement, prevention, and medication of the disease have been continually improved ...
Astawa, N. M. (N), Sukardika, K. (K), Sukrama, I. D. (I), Sumarno, S. (Sumarno)   +3 more
core  

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source