Results 111 to 120 of about 4,033,279 (373)
REINFORCEMENT OF INHIBITION [PDF]
Journal of the Experimental Analysis of Behavior, 1983 A differential‐reinforcement‐of‐other‐behavior (DRO) schedule with trials and delayed reinforcement was investigated. Periodically a wheel was briefly available to rats, followed six seconds later by brief availability of a bar. Variable‐ratio food reinforcement of wheel turns was adjusted to give 95% turns.
openaire +3 more sources
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Drvna Industrija, 2013 Studies were carried out on the influence of Prunus africana heartwood extractives on the growth of selected wood decay fungi. Also, wood chemical and mineral content, dimensional stability and anatomical features of P. africana were studied.
Francis Mburu +4 more
doaj
Frontiers in Human Neuroscience, 2015 In right-handers, an increase in the pace of dominant hand movement results in increased ipsilateral deactivation of the primary motor cortex (M1). By contrast, an increase in non-dominant hand movement frequency is associated with reduced ipsilateral ...
Nathalie eTzourio-Mazoyer +8 more
doaj +1 more source
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Is lithium a universal inhibitor? Evidence arising from clinical neuroscience and oncology
Dialogues in Clinical Neuroscience & Mental Health, 2019 Lithium has been in the environment from the origin of life, interacting with almost all of the biological molecules that life invented. Lithium affects many components of intracellular signalling pathways, inhibiting more than ten cellular targets and ...
Orestis Giotakos
doaj +1 more source
Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations.
New England Journal of Medicine, 2012 BACKGROUND Resistance to therapy with BRAF kinase inhibitors is associated with reactivation of the mitogen-activated protein kinase (MAPK) pathway. To address this problem, we conducted a phase 1 and 2 trial of combined treatment with dabrafenib, a ...
K. Flaherty +25 more
semanticscholar +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Molecules, 2012  Nε-(carboxymethyl) lysine (CML) is the most abundant advanced glycation end product (AGE), and frequently selected as an AGEs marker in laboratory studies.
Bing Li +6 more
doaj +1 more source