Results 111 to 120 of about 4,254,417 (298)

Selective attention and inhibition in young school-aged children [PDF]

open access: yesSpecijalna Edukacija i Rehabilitacija, 2019
The aims of this research were to determine the developmental dynamics of selective attention and inhibition in younger school-aged children, as well as its relationship with gender and intellectual abilities.
Gligorović Milica, Buha Nataša
doaj  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

IMPLICATIONS OF Acanthus ilicifolius LEAF EXTRACT UTILIZATION TO INHIBIT Candida albicans GROWTH TO SUPPORT MANGROVE CONSERVATION

open access: yesJurnal Teknologi Perikanan dan Kelautan
Acanthus ilicifolius, a mangrove species with known therapeutic material, was investigated for its ability to inhibit the growth of Candida albicans. This study aimed to analyze the potential inhibitory effect of A.
Maulinna Kusumo Wardhani, Askur Rahman
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Nitric oxide synthases: structure, function and inhibition.

open access: yesBiochemical Journal, 2001
W. Alderton   +2 more
semanticscholar   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Evidence for pericyte origin of TSC-associated renal angiomyolipomas and implications for angiotensin receptor inhibition therapy

open access: green, 2014
Brian J. Siroky   +11 more
openalex   +1 more source

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