Results 181 to 190 of about 4,778,507 (336)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Notes on the formation and inhibition of mildew in paints [PDF]

, 1913
Henry A. Gardner
openalex   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Common Food Additives Inhibit Carbonic Anhydrase Activity. [PDF]

J Biochem Mol Toxicol
Karaçelik AA, Küçük M, Türkuçar SA, Beydemir Ş.   +3 more
europepmc   +1 more source

INHIBITION OF COLOR DEVELOPMENT IN THE LOWRY-LOPEZ PHOSPHORUS METHOD BY SULFHYDRYL COMPOUNDS AND ITS COUNTERACTION BY COPPER

, 1956
J.H. Bruemmer, Boyd L. O’Dell
openalex   +1 more source

STUDIES IN THE NATURAL AND ARTIFICIAL INHIBITION OF PEPTIC DIGESTION [PDF]

, 1907
Joseph Sailer, CLIFFORD B. FARR
openalex   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Development, validation, and application of a dual-color fluorescent assay for high-throughput screening of anti-chikungunya drugs. [PDF]

Sci Rep
Sawetpiyakul P, Peypala D, Wiriwithya P, Phanomchoeng G, Khotavivattana T, Chavasiri W, Pattaradilokrat S, Boonyasuppayakorn S.   +7 more
europepmc   +1 more source

THE INHIBITION OF TRYPSIN

, 1955
T. Viswanatha, Irvin E. Liener
openalex   +1 more source

On The Nature of Inhibition, And The Action of Drugs Upon it 1 [PDF]

, 1883
T. Lauder Brunton
openalex   +1 more source