Results 11 to 20 of about 4,033,279 (373)

Naringenin derivatives as glucosamine-6-phosphate synthase inhibitors: synthesis, antioxidants, antimicrobial, preservative efficacy, molecular docking and in silico ADMET analysis

BMC Chemistry, 2020
Background Preservatives have to be added in food, pharmaceuticals and cosmetics products to maintain their shelf life. However, the existing chemical based preservatives have been associated with severe side effects that compel the researchers to find ...
Amit Lather, Sunil Sharma, Anurag Khatkar   +2 more
doaj   +1 more source

Lead optimization for promising monoamine oxidase inhibitor from eugenol for the treatment of neurological disorder: synthesis and in silico based study

BMC Chemistry, 2019
Natural based inhibitors of monoamine oxidase are promising drug candidates for the treatment of several neurodegenerative and neuropsychological disorders including depression, anxiety, Parkinson’s disease and Alzheimer’s disease.
Priyanka Dhiman, Neelam Malik, Anurag Khatkar   +2 more
doaj   +1 more source

Natural based piperine derivatives as potent monoamine oxidase inhibitors: an in silico ADMET analysis and molecular docking studies

BMC Chemistry, 2020
Neurodegenerative disorders follow numerous pathological ways concerning overexpression of monoamine oxidase and formation of reactive oxygen species.
Priyanka Dhiman, Neelam Malik, Anurag Khatkar   +2 more
doaj   +1 more source

Angiotensin-neprilysin inhibition versus enalapril in heart failure.

New England Journal of Medicine, 2014
BACKGROUND We compared the angiotensin receptor-neprilysin inhibitor LCZ696 with enalapril in patients who had heart failure with a reduced ejection fraction. In previous studies, enalapril improved survival in such patients.
J. McMurray, M. Packer, Akshay S. Desai, J. Gong, M. Lefkowitz, A. Rizkala, J. Rouleau, V. Shi, S. Solomon, K. Swedberg, M. Zile   +10 more
semanticscholar   +1 more source

Hybrid caffeic acid derivatives as monoamine oxidases inhibitors: synthesis, radical scavenging activity, molecular docking studies and in silico ADMET analysis

Chemistry Central Journal, 2018
Background Monoamine oxidase has been implicated in numerous neurological disorders. Although synthetic monoamine oxidase inhibitors (MAOI) have emerged with many side effects, the aspiration of natural based MAOI has greatly increased.
Priyanka Dhiman, Neelam Malik, Anurag Khatkar   +2 more
doaj   +1 more source

Inhibition [PDF]

The Pedagogical Seminary, 1898
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openaire   +2 more sources

Amygdalin based G-6-P synthase inhibitors as novel preservatives for food and pharmaceutical products

Scientific Reports, 2020
G-6-P synthase enzyme has been involved in the synthesis of the microbial cell wall, and its inhibition may lead to the antimicrobial effect. In the present study, we designed a library of amygdalin derivatives, and two most active derivatives selected ...
Amit Lather, Sunil Sharma, Anurag Khatkar   +2 more
doaj   +1 more source

Disruption of KCC2 in Parvalbumin-Positive Interneurons Is Associated With a Decreased Seizure Threshold and a Progressive Loss of Parvalbumin-Positive Interneurons

Frontiers in Molecular Neuroscience, 2022
GABAA receptors are ligand-gated ion channels, which are predominantly permeable for chloride. The neuronal K-Cl cotransporter KCC2 lowers the intraneuronal chloride concentration and thus plays an important role for GABA signaling. KCC2 loss-of-function
Tanja Herrmann, Melanie Gerth, Ralf Dittmann, Daniel Pensold, Martin Ungelenk, Lutz Liebmann, Christian A. Hübner   +6 more
doaj   +1 more source

In-silico design, synthesis, ADMET studies and biological evaluation of novel derivatives of Chlorogenic acid against Urease protein and H. Pylori bacterium

BMC Chemistry, 2019
Background Plants have always played important role in treating human and animal diseases as a therapeutic agent for traditional medicine. Through extensive research throughout the world, potential of natural products have been identified to control the ...
Ritu Kataria, Anurag Khatkar
doaj   +1 more source

Cognitive Control in Suicide Ideators and Suicide Attempters

Frontiers in Psychology, 2020
There is a need to understand more of the risk factors involved in the process from suicide ideation to suicide attempt. Cognitive control processes may be important factors in assessing vulnerability to suicide.
Silje Støle Brokke, Silje Støle Brokke, Nils Inge Landrø, Nils Inge Landrø, Vegard Øksendal Haaland, Vegard Øksendal Haaland   +5 more
doaj   +1 more source