Results 21 to 30 of about 4,234,264 (316)

Tumor Mutational Burden and Response Rate to PD-1 Inhibition

New England Journal of Medicine, 2017
In a survey of the spectrum of mutational burdens in 27 types of cancers, there was a correlation between an increased mutational burden and the response to checkpoint inhibition of PD-1 and PD-L1.
M. Yarchoan, Alexander C. Hopkins, E. Jaffee   +2 more
semanticscholar   +1 more source

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

Cell, 2013
Summary Chromatin regulators have become attractive targets for cancer therapy, but it is unclear why inhibition of these ubiquitous regulators should have gene-specific effects in tumor cells.
Jakob Lovén, Heather A. Hoke, Charles Y. Lin, Ashley Lau, David A. Orlando, C. Vakoc, J. Bradner, Tong Ihn Lee, R. Young   +8 more
semanticscholar   +1 more source

Combined effect of heavy metals on the activated sludge process; pp. 305–314 [PDF]

Proceedings of the Estonian Academy of Sciences, 2018
Migration of heavy metals in the environment is a serious problem for wastewater treatment plants (WWTP) and the environment as a whole. The combined effect of eight heavy metals on the biological wastewater treatment process was analysed in this ...
Erki Lember, Vitali Retšnoi, Karin Pachel, Enn Loigu   +3 more
doaj   +1 more source

Acquired Resistance to KRASG12C Inhibition in Cancer

New England Journal of Medicine, 2021
BACKGROUND Clinical trials of the KRAS inhibitors adagrasib and sotorasib have shown promising activity in cancers harboring KRAS glycine-to-cysteine amino acid substitutions at codon 12 (KRASG12C).
M. Awad, Shengwu Liu, I. Rybkin, K. Arbour, Julien Dilly, V. Zhu, M. Johnson, R. Heist, T. Patil, Gregory Riely, J. Jacobson, Xiaoping Yang, N. Persky, D. Root, Kristen E. Lowder, Hanrong Feng, Shannon S Zhang, K. Haigis, Y. Hung, L. Sholl, B. Wolpin, Julie Wiese, J. Christiansen, Jessica K. Lee, A. Schrock, L. Lim, K. Garg, Mark Li, Lars D. Engstrom, L. Waters, J. Lawson, P. Olson, P. Lito, S. Ou, J. Christensen, P. Jänne, A. Aguirre   +36 more
semanticscholar   +1 more source

The Detection of Potential Native Probiotics Lactobacillus spp. against Salmonella Enteritidis, Salmonella Infantis and Salmonella Kentucky ST198 of Lebanese Chicken Origin

Antibiotics, 2022
Salmonella continues to be a major threat to public health, especially with respect to strains from a poultry origin. In recent years, an increasing trend of antimicrobial resistance (AMR) in Salmonella spp. was observed due to the misuse of antibiotics.
Rima El Hage, Jeanne El Hage, Selma P. Snini, Imad Ammoun, Joseph Touma, Rami Rachid, Florence Mathieu, Jean-Marc Sabatier, Ziad Abi Khattar, Youssef El Rayess   +9 more
doaj   +1 more source

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

New England Journal of Medicine, 2010
Background The identification of somatic mutations in the gene encoding the serine–threonine protein kinase B-RAF (BRAF) in the majority of melanomas offers an opportunity to test oncogene-targeted therapy for this disease.
K. Flaherty, I. Puzanov, Kevin B. Kim, A. Ribas, G. McArthur, J. Sosman, P. O'dwyer, Richard J Lee, J. Grippo, K. Nolop, P. Chapman   +10 more
semanticscholar   +1 more source

Atık Yağ, Gres ve Lipid Maddeleri ile Uzun Zincirli Yağ Asitlerinin Anaerobik Prosesle Arıtılabilirliği Üzerine Derleme Çalışması

Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2022
Bu derleme çalışması kapsamında yağ, gres ve lipid maddelerinden (YGLM) anaerobik biyoteknoloji ile biyoenerji eldesi, atıksulardaki kaynakları, oluşumları, biyolojik parçalanma özellikleri, anaerobik arıtım mikrobiyolojisi ve uygulamaları incelenmiştir.
Dilek Erdirencelebi
doaj   +1 more source

Anaplastic Lymphoma Kinase Inhibition in Non–Small-Cell Lung Cancer

New England Journal of Medicine, 2010
BACKGROUND Oncogenic fusion genes consisting of EML4 and anaplastic lymphoma kinase (ALK) are present in a subgroup of non–small-cell lung cancers, representing 2 to 7% of such tumors. We explored the therapeutic efficacy of inhibiting ALK in such tumors
Eunice Lee Kwak, Y. Bang, D. Camidge, Alice T. Shaw, B. Solomon, Robert G. Maki, Sai-Hong Ignatius Ou, B. Dezube, P. Jänne, D. B. Costa, M. Varella-Garcia, W. Kim, Thomas J. Lynch, P. Fidias, Hannah Stubbs, J. Engelman, L. Sequist, Weiwei Tan, L. Gandhi, M. Mino‐Kenudson, Greg C. Wei, S. M. Shreeve, M. Ratain, Jeffrey Settleman, James G. Christensen, Daniel A. Haber, K. Wilner, R. Salgia, Geoffrey I. Shapiro, J. Clark, A. Iafrate   +30 more
semanticscholar   +1 more source

Short-Term and Long-Term Inhibitory Effects of Copper on Anammox Process

Proceedings, 2018
The main goal of this study is to evaluate the short-term and long-term inhibitory effects of Cu (II) on Anammox process. To investigate the short-term inhibition level, four different concentrations (1, 2.5, 5 and 10 mg L−1 as Cu2+) were tested in batch
Cigdem Kalkan Aktan, Ayse Ekin Uzunhasanoglu, Kozet Yapsakli, Bulent Mertoglu   +3 more
doaj   +1 more source

IN-VITRO INHIBITION TEST OF KEJI BELING (STROBILANTHES CRISPUS) CRUDE EXTRACT ON EDWARDSIELLA TARDA [PDF]

Russian Journal of Agricultural and Socio-Economic Sciences, 2022
Bacterial infections, such as Edwardsiella tarda, can cause fish diseases. The onset of the disease is the least expected by the cultivators because it can result in economic losses.
Heny S., Arief P., Manggar R.N.V.
doaj