Results 21 to 30 of about 6,398,774 (357)

Consensus statement on blocking the effects of interleukin-6 and in particular by interleukin-6 receptor inhibition in rheumatoid arthritis and other inflammatory conditions

Annals of the Rheumatic Diseases, 2012
Background Since approval of tocilizumab (TCZ) for treatment of rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA), interleukin 6 (IL-6) pathway inhibition was evaluated in trials of TCZ and other agents targeting the IL-6 receptor and ...
Josef S Smolen, M. Schoels, Norihiro Nishimoto, F. C. Breedveld, G. Burmester, M. Dougados, P. Emery, Gianfranco Ferraccioli, C. Gabay, A. Gibofsky, J. Gómez-Reino, G. Jones, T. Kvien, M. Murakami, N. Betteridge, Clifton O. Bingham, Vivian Bykerk, Ernest Choy, Bernard Combe, Maurizio Cutolo, W. Graninger, Á. Lanas, E. Martín-Mola, C. Montecucco, M. Ostergaard, Karel Pavelka, A. Rubbert-Roth, N. Sattar, M. Scholte-Voshaar, Yoshiya Tanaka, Michael Trauner, G. Valentini, Kevin L Winthrop, M. de Wit, D. M. van der Heijde   +34 more
semanticscholar   +1 more source

Neural correlates of intentional and stimulus-driven inhibition: a comparison [PDF]

, 2014
People can inhibit an action because of an instruction by an external stimulus, or because of their own internal decision. The similarities and differences between these two forms of inhibition are not well understood. Therefore, in the present study the
Brass, Marcel, Crone, Eveline A, Haggard, Patrick, Kühn, Simone, Ridderinkhof, K Richard, Schel, Margot A   +5 more
core   +5 more sources

Amygdalin based G-6-P synthase inhibitors as novel preservatives for food and pharmaceutical products

Scientific Reports, 2020
G-6-P synthase enzyme has been involved in the synthesis of the microbial cell wall, and its inhibition may lead to the antimicrobial effect. In the present study, we designed a library of amygdalin derivatives, and two most active derivatives selected ...
Amit Lather, Sunil Sharma, Anurag Khatkar   +2 more
doaj   +1 more source

Angiotensin-neprilysin inhibition versus enalapril in heart failure.

New England Journal of Medicine, 2014
BACKGROUND We compared the angiotensin receptor-neprilysin inhibitor LCZ696 with enalapril in patients who had heart failure with a reduced ejection fraction. In previous studies, enalapril improved survival in such patients.
J. McMurray, M. Packer, Akshay S. Desai, J. Gong, M. Lefkowitz, A. Rizkala, J. Rouleau, V. Shi, S. Solomon, K. Swedberg, M. Zile   +10 more
semanticscholar   +1 more source

PARP inhibition: a promising therapeutic target in ovarian cancer [PDF]

, 2015
Ovarian cancer is burdened by the highest mortality rate among gynecological cancers. Gold standard is represented by the association of platinum-taxane -based chemotherapy and radical surgery.
Abdul Halim, T, BENEDETTI PANICI, PIERLUIGI, CASORELLI, ASSUNTA, DI DONATO, VIOLANTE, DOMENICI, LAVINIA, GASPARRI, MARIALUISA, IMPERIALE, LUDOVICA, MARCHETTI, CLAUDIA, MONTI, Marco, MUSELLA, ANGELA, MUZII, LUDOVICO, PALAIA, INNOCENZA, PECORINI, Francesco, RUSCITO, ILARY, SALERNO, LAURA   +14 more
core   +1 more source

In-silico design, synthesis, ADMET studies and biological evaluation of novel derivatives of Chlorogenic acid against Urease protein and H. Pylori bacterium

BMC Chemistry, 2019
Background Plants have always played important role in treating human and animal diseases as a therapeutic agent for traditional medicine. Through extensive research throughout the world, potential of natural products have been identified to control the ...
Ritu Kataria, Anurag Khatkar
doaj   +1 more source

Allosteric Inhibition of Factor XIIIa. Non-Saccharide Glycosaminoglycan Mimetics, but Not Glycosaminoglycans, Exhibit Promising Inhibition Profile [PDF]

, 2016
Factor XIIIa (FXIIIa) is a transglutaminase that catalyzes the last step in the coagulation process. Orthostery is the only approach that has been exploited to design FXIIIa inhibitors.
Afosa, Daniel K., Al-Horani, Rami A., Desai, Umesh R., Karuturi, Rajesh, Lee, Michael   +4 more
core   +7 more sources

In silico design and synthesis of hesperitin derivatives as new xanthine oxidase inhibitors

BMC Chemistry, 2019
Background Hesperitin, a naturally occurring flavonoid was hybridized with phenolic acids to evaluate its potential to inhibit the activity of xanthine oxidase (XO), a key enzyme which catalyses xanthine to uric acid which is found to be associated with ...
Neelam Malik, Priyanka Dhiman, Anurag Khatkar   +2 more
doaj   +1 more source

In Vitro Inhibition Effects of 2-Amino Thiazole Derivatives on Lactoperoxidase Enzyme Activity

Cumhuriyet Science Journal, 2022
Lactoperoxidase (LPO E.C. 1.11.1.7) is a member of the peroxidase family and is an important glycoprotein containing heme group in its structure and showing the antimicrobial effect on disease causing microorganisms in the digestive system of newborn ...
Işıl Nihan Korkmaz
doaj   +1 more source

Event-related brain potentials in the study of inhibition: cognitive control, source localization and age-related modulations [PDF]

, 2014
In the previous 15 years, a variety of experimental paradigms and methods have been employed to study inhibition. In the current review, we analyze studies that have used the high temporal resolution of the event-related potential (ERP) technique to ...
Guerrini, Chiara, Leitao, Jose, Leitão, José, Pires, Luis, Pires, Luís, Simoes, Mario R., Simões, Mário R.   +6 more
core   +2 more sources