Results 11 to 20 of about 4,234,264 (316)
BMC Chemistry, 2019 Background Plants have always played important role in treating human and animal diseases as a therapeutic agent for traditional medicine. Through extensive research throughout the world, potential of natural products have been identified to control the ...
Ritu Kataria, Anurag Khatkar
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In Vitro Inhibition Effects of 2-Amino Thiazole Derivatives on Lactoperoxidase Enzyme Activity
Cumhuriyet Science Journal, 2022 Lactoperoxidase (LPO E.C. 1.11.1.7) is a member of the peroxidase family and is an important glycoprotein containing heme group in its structure and showing the antimicrobial effect on disease causing microorganisms in the digestive system of newborn ...
Işıl Nihan Korkmaz
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In silico design and synthesis of hesperitin derivatives as new xanthine oxidase inhibitors
BMC Chemistry, 2019 Background Hesperitin, a naturally occurring flavonoid was hybridized with phenolic acids to evaluate its potential to inhibit the activity of xanthine oxidase (XO), a key enzyme which catalyses xanthine to uric acid which is found to be associated with ...
Neelam Malik +2 more
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BMC Chemistry, 2019 Background Urease are responsible for several pathogenic states in human as well as in animals and its inhibition is utmost urgent. Clinically used drugs are associated with many side effects; recently several researches have shown that flavonoids have ...
Ritu Kataria, Anurag Khatkar
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Selective inhibition of BET bromodomains
Nature, 2010 Epigenetic proteins are intently pursued targets in ligand discovery. So far, successful efforts have been limited to chromatin modifying enzymes, or so-called epigenetic ‘writers’ and ‘erasers’.
P. Filippakopoulos +24 more
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Clinical Chemistry, 2019 Some old methods are still in use because they are simple and effective. One such method is the disk diffusion (or agar diffusion) test (1, 2). The diameter of the clear zone around an antibiotic-paper disk enables us to directly, and elegantly, visualize the inhibitory potency of an antibiotic. This test is …
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In silico design and synthesis of targeted rutin derivatives as xanthine oxidase inhibitors
BMC Chemistry, 2019 Background Xanthine oxidase is an important enzyme of purine catabolism pathway and has been associated directly in pathogenesis of gout and indirectly in many pathological conditions like cancer, diabetes and metabolic syndrome.
Neelam Malik +2 more
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Angiotensin-Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction.
New England Journal of Medicine, 2019 BACKGROUND The angiotensin receptor-neprilysin inhibitor sacubitril-valsartan led to a reduced risk of hospitalization for heart failure or death from cardiovascular causes among patients with heart failure and reduced ejection fraction.
S. Solomon +33 more
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Materials Research Express, 2023 For many decades, Cu ^2+ ions have been used as fungicides in agriculture. However, the accumulation of Cu ^2+ ions in the soil ecosystem will be disadvantage for environment.
Hanh Thi Truong +2 more
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