Results 251 to 260 of about 4,254,417 (298)

Spectroscopic Methods in Evaluation of Antioxidant Potential, Enzyme Inhibition, Cytotoxicity, and Antimicrobial Activity of the Synthesized <i>N</i>³-Substituted Amidrazones. [PDF]

Int J Mol Sci
Paprocka R, Pazderski L, Kutkowska J, Naeem I, Awan AS, Mushtaq Z, Szydłowska-Czerniak A.   +6 more
europepmc   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

BCOR mutations define a therapeutic vulnerability to DHODH Inhibition in acute myeloid leukemia. [PDF]

Ann Hematol
Robert F, Badja C, Boushaki S, Degasperi A, Memari Y, Momen S, Roumeliotis TI, Kozik Z, Gozdecka M, Choudhary J, Vassiliou G, Koh GC, Nik-Zainal S.   +12 more
europepmc   +1 more source

The TAAR1 antagonist EPPTB ameliorates colitis via serotonin inhibition

Leyi Luo, Tong Zhang, Linlin Liang, Weixin Chen, Tao Wang, Wenke Chen, HaiTao Xiao, Guangtao Zhang   +7 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Investigating the antioxidant, antibacterial, and antifungal properties of typha domingensis leaves assisted synthesized zinc oxide nanoparticles. [PDF]

PLoS One
Ahmed MS, Setu MAI, Goswami A, Sultana MS, Dhar PK, Haque MR, Dutta SK.   +6 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Investigating operational stability and causes of cofactor release in fold type I amine transaminase. [PDF]

Protein Sci
Feng X, Chau W, Master ER.
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source