Results 261 to 270 of about 6,274,440 (386)

SYMPATHETIC INHIBITION OF THE LARGE INTESTINE IN HIRSCHSPRUNG'S DISEASE 1 [PDF]

, 1930
W. J. MERLE SCOTT, John J. Morton
openalex   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders

Molecular Psychiatry, 2019
V. Sohal, J. Rubenstein
semanticscholar   +1 more source

Multitarget Compounds Designed for Alzheimer, Parkinson, and Huntington Neurodegeneration Diseases. [PDF]

Pharmaceuticals (Basel)
Katsoulaki EE, Dimopoulos D, Hadjipavlou-Litina D.   +2 more
europepmc   +1 more source

OBSERVATIONS ON THE SPECIFICITY OF THE INHIBITION OF CHOLINESTERASES BY TRI‐ORTHO‐CRESYL PHOSPHATE [PDF]

, 1953
C. J. Earl, Robert Thompson, G. R. Webster   +2 more
openalex   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

Nature Network Boston, 2019
Kirsten L. Bryant, Clint A. Stalnecker, Daniel Zeitouni, Jennifer E. Klomp, S. Peng, A. Tikunov, V. Gunda, M. Pierobon, Andrew M. Waters, Samuel D. George, Garima Tomar, Bjoern Papke, G. A. Hobbs, Liang Yan, T. Hayes, J. Diehl, G. Goode, Nina V. Chaika, Yingxue Wang, Guo-Fang Zhang, A. Witkiewicz, E. Knudsen, E. Petricoin, P. Singh, J. Macdonald, N. Tran, C. Lyssiotis, H. Ying, Alec C. Kimmelman, A. Cox, C. Der   +30 more
semanticscholar   +1 more source

A Ketol-Acid Reductoisomerase Inhibitor That Has Antituberculosis and Herbicidal Activity. [PDF]

Chemistry
Lin X, Kurz JL, Li YH, Wun SJ, Lonhienne T, McGeary RP, West NP, Schenk G, Wang JG, Guddat LW.   +9 more
europepmc   +1 more source

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source