Results 21 to 30 of about 4,033,279 (373)
Flavonoids as inhibitors of human neutrophil elastase
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 Elastase is a proteolytic enzyme belonging to the family of hydrolases produced by human neutrophils, monocytes, macrophages, and endothelial cells.
Katarzyna Jakimiuk +3 more
doaj +1 more source
BMC Chemistry, 2019 Background Urease are responsible for several pathogenic states in human as well as in animals and its inhibition is utmost urgent. Clinically used drugs are associated with many side effects; recently several researches have shown that flavonoids have ...
Ritu Kataria, Anurag Khatkar
doaj +1 more source
Synthesis and evaluation of AKR1C inhibitory properties of A-ring halogenated oestrone derivatives
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 Enzymes AKR1C regulate the action of oestrogens, androgens, and progesterone at the pre-receptor level and are also associated with chemo-resistance. The activities of these oestrone halides were investigated on recombinant AKR1C enzymes.
Maša Sinreih +6 more
doaj +1 more source
In silico design and synthesis of hesperitin derivatives as new xanthine oxidase inhibitors
BMC Chemistry, 2019 Background Hesperitin, a naturally occurring flavonoid was hybridized with phenolic acids to evaluate its potential to inhibit the activity of xanthine oxidase (XO), a key enzyme which catalyses xanthine to uric acid which is found to be associated with ...
Neelam Malik +2 more
doaj +1 more source
Nitric oxide synthases: structure, function and inhibition.
Biochemical Journal, 2001 This review concentrates on advances in nitric oxide synthase (NOS) structure, function and inhibition made in the last seven years, during which time substantial advances have been made in our understanding of this enzyme family.
W. Alderton +2 more
semanticscholar +1 more source
In silico design and synthesis of targeted rutin derivatives as xanthine oxidase inhibitors
BMC Chemistry, 2019 Background Xanthine oxidase is an important enzyme of purine catabolism pathway and has been associated directly in pathogenesis of gout and indirectly in many pathological conditions like cancer, diabetes and metabolic syndrome.
Neelam Malik +2 more
doaj +1 more source
Spontaneous emission inhibition of telecom-band quantum disks inside single nanowire on different substrates [PDF]
Optics Express, Vol. 22, Issue 10, pp. 11713-11726 (2014), 2014 We investigate the inhibited spontaneous emission of telecom-band InAs quantum disks (Qdisks) in InP nanowires (NWs). We have evaluated how the inhibition is affected by different disk diameter and thickness. We also compared the inhibition in standing InP NWs and those NWs laying on silica (SiO2), and silicon (Si) substrates.
arxiv +1 more source
Selective inhibition of BET bromodomains
Nature, 2010 Epigenetic proteins are intently pursued targets in ligand discovery. So far, successful efforts have been limited to chromatin modifying enzymes, or so-called epigenetic ‘writers’ and ‘erasers’.
P. Filippakopoulos +24 more
semanticscholar +1 more source
Angiotensin-Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction.
New England Journal of Medicine, 2019 BACKGROUND The angiotensin receptor-neprilysin inhibitor sacubitril-valsartan led to a reduced risk of hospitalization for heart failure or death from cardiovascular causes among patients with heart failure and reduced ejection fraction.
S. Solomon +33 more
semanticscholar +1 more source