Results 21 to 30 of about 4,254,417 (298)

Acquired Resistance to KRASG12C Inhibition in Cancer.

New England Journal of Medicine, 2021
BACKGROUND Clinical trials of the KRAS inhibitors adagrasib and sotorasib have shown promising activity in cancers harboring KRAS glycine-to-cysteine amino acid substitutions at codon 12 (KRASG12C).
M. Awad, Shengwu Liu, I. Rybkin, K. Arbour, Julien Dilly, V. Zhu, M. Johnson, R. Heist, T. Patil, Gregory Riely, J. Jacobson, Xiaoping Yang, N. Persky, D. Root, Kristen E. Lowder, Hanrong Feng, Shannon S Zhang, K. Haigis, Y. Hung, L. Sholl, B. Wolpin, Julie Wiese, J. Christiansen, Jessica K. Lee, A. Schrock, L. Lim, K. Garg, Mark Li, Lars D. Engstrom, L. Waters, J. Lawson, P. Olson, P. Lito, S. Ou, J. Christensen, P. Jänne, A. Aguirre   +36 more
semanticscholar   +1 more source

Short-Term and Long-Term Inhibitory Effects of Copper on Anammox Process

Proceedings, 2018
The main goal of this study is to evaluate the short-term and long-term inhibitory effects of Cu (II) on Anammox process. To investigate the short-term inhibition level, four different concentrations (1, 2.5, 5 and 10 mg L−1 as Cu2+) were tested in batch
Cigdem Kalkan Aktan, Ayse Ekin Uzunhasanoglu, Kozet Yapsakli, Bulent Mertoglu   +3 more
doaj   +1 more source

IN-VITRO INHIBITION TEST OF KEJI BELING (STROBILANTHES CRISPUS) CRUDE EXTRACT ON EDWARDSIELLA TARDA [PDF]

Russian Journal of Agricultural and Socio-Economic Sciences, 2022
Bacterial infections, such as Edwardsiella tarda, can cause fish diseases. The onset of the disease is the least expected by the cultivators because it can result in economic losses.
Heny S., Arief P., Manggar R.N.V.
doaj  

Atık Yağ, Gres ve Lipid Maddeleri ile Uzun Zincirli Yağ Asitlerinin Anaerobik Prosesle Arıtılabilirliği Üzerine Derleme Çalışması

Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2022
Bu derleme çalışması kapsamında yağ, gres ve lipid maddelerinden (YGLM) anaerobik biyoteknoloji ile biyoenerji eldesi, atıksulardaki kaynakları, oluşumları, biyolojik parçalanma özellikleri, anaerobik arıtım mikrobiyolojisi ve uygulamaları incelenmiştir.
Dilek Erdirencelebi
doaj   +1 more source

POTENTIAL BACTERICIDAL ACTION OF UHF ON THE STRAINS OF MYCOBACTERIUM AVIUM AND MYCOBACTERIUM TUBERCULOSIS

Туберкулез и болезни лёгких, 2019
The objective of the study: to assess the potential bactericidal action of UHF on Mycobacterium avium strain104 and Mycobacterium tuberculosis strain H37Rv.Subjects and methods: M. avium strain 104 and M.
B. L. Ikhlov, A. A. Shurygin, V. A. Drobkova   +2 more
doaj   +1 more source

Shaping Functional Architecture by Oscillatory Alpha Activity: Gating by Inhibition

Frontiers in Human Neuroscience, 2010
In order to understand the working brain as a network, it is essential to identify the mechanisms by which information is gated between regions. We here propose that information is gated by inhibiting task-irrelevant regions, thus routing information to ...
O. Jensen, A. Mazaheri
semanticscholar   +1 more source

KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors.

New England Journal of Medicine, 2020
BACKGROUND No therapies for targeting KRAS mutations in cancer have been approved. The KRAS p.G12C mutation occurs in 13% of non-small-cell lung cancers (NSCLCs) and in 1 to 3% of colorectal cancers and other cancers.
D. Hong, M. Fakih, J. Strickler, J. Desai, G. Durm, G. Shapiro, G. Falchook, T. Price, A. Sacher, C. Denlinger, Y. Bang, G. Dy, J. Krauss, Y. Kuboki, J. Kuo, A. Coveler, Keunchil Park, Tae Won Kim, F. Barlesi, P. Munster, S. Ramalingam, T. Burns, F. Meric-Bernstam, H. Henary, J. Ngang, G. Ngarmchamnanrith, June Kim, B. Houk, J. Canon, J. Lipford, G. Friberg, P. Lito, R. Govindan, Bob T. Li   +33 more
semanticscholar   +1 more source

Pazopanib Combined With Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale, Alessandro Crocoli, Giuseppe Maria Milano, Pierluigi Di Paolo, Francesca Diomedi Camassei, Ida Russo, Annalisa Serra   +6 more
wiley   +1 more source

Nutritional and Behavioral Intervention for Long‐Term Childhood Acute Leukemia Survivors With Metabolic Syndrome

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Metabolic syndrome (MetS) is a common complication in survivors of childhood acute lymphoblastic and myeloid leukemia (AL), and a major risk factor for premature cardiovascular disease, type‐2‐diabetes, and metabolic dysfunction‐associated steatotic liver disease (MASLD).
Visentin Sandrine, Béliard Sophie, Renard Cécile, Caussy Cyrielle, Hamidou Zeinab, Romano David, Gacem Mélanie, Petit Arnaud, Saultier Paul, Borentain Patrick, Michel Gérard   +10 more
wiley   +1 more source

Potential anticholinesterase of plants of the Caatinga biome / Potencial anticolinesterásico de plantas do bioma Caatinga

Diversitas Journal, 2018
The caatinga is the only exclusive biome in Brazil, characterized by arboreal or arbusive vegetation, composed of small trees and shrubs of xerophytic peculiarities.
Anderson Soares de Almeida, Aldenir Feitosa dos Santos   +1 more
doaj   +1 more source